TY - JOUR ID - 11377 TI - Is Subclinical Thyroid Dysfunction Associated With with Coronary Heart Disease? JO - Journal of Cardio-Thoracic Medicine JA - JCTM LA - en SN - 2345-2447 AU - Barghchi, Elaheh AU - Azizi, Fereidoun AD - Internal Medicine, Department of Endocrinology, University of Medical Sciences, Mashhad, Iran. AD - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Y1 - 2018 PY - 2018 VL - 6 IS - 3 SP - 338 EP - 343 KW - Coronary Heart Disease KW - Cardiovascular Mortality KW - Subclinical Thyroid Disorders   DO - 10.22038/jctm.2018.33242.1172 N2 - Introduction: Previous cohort studies reported contradictory data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD). Regarding this, the present study was conducted to illuminate this relationship. Materials and Methods: For the purpose of the study, 3,066 participants employed in a study conducted by Azizi et al. aged ≥ 20 years were subjected to thyroid function tests every 3 years over a mean follow-up of 10 years. After the exclusion of the subjects with CHD and those consumed thyroid, anti-thyroid, or corticosteroid preparations, 2,144 subjects remained for analysis and followed up for CHD events in the next 10 years. Results: At the baseline, 1929, 139, and 76 subjects had euthyroid, subclinical hyperthyroid, and subclinical hypothyroid, respectively. No CHD event occurred in the subclinical hypothyroid group. After the adjustment of all confounders, the subclinical hyperthyroid group had the hazard ratio of 1.01 for CHD with a 95% confidence interval of 0.36-2.85. Conclusions: The 10 year follow-up of subjects with subclinical thyroid disease revealed no relationship between CHD and subclinical thyroid disorders. UR - https://jctm.mums.ac.ir/article_11377.html L1 - https://jctm.mums.ac.ir/article_11377_60cdac69b591a43b32d8ef43ad2def43.pdf ER -