TY - JOUR ID - 2608 TI - A comparison of HTLV-1 Infection Frequency in Patients with or without Tuberculosis JO - Journal of Cardio-Thoracic Medicine JA - JCTM LA - en SN - 2345-2447 AU - Ghofraniha, Leila AU - Ghalenavi, Elham AU - Attaran, Davood AU - Towhidi, Mohammad AU - Rafatpanah, Hooshang AU - Khajehdaloee, Mohamad AU - Sarvghad Moghadam, Mohamad Reza AD - Pulmonologist, Chronic Obstructive Pulmonary Disease Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Internist, Chronic Obstructive Pulmonary Disease Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Pulmonologist, Cardio‐Thoracic Surgery & Transplant Research Center, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Immunologist, Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Community Medicine Specialist, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Infectious Disease Department, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2014 PY - 2014 VL - 2 IS - 2 SP - 143 EP - 146 KW - Case-Control KW - HTLV-1 KW - Immunosuppression KW - Tuberculosis DO - 10.22038/jctm.2014.2608 N2 - Introduction: To recognize the predisposing factors in tuberculosis as an endemic infection in Northeast province of Iran, this study was aimed to evaluate whether HumanT-lymphocyte type 1 (HTLV-I) as an immunosuppressive factor increases the risk of tuberculosis. Materials and Methods: A Case-control study was conducted in 278 tuberculosis patients from 2007 to 2010, in Mashhad, Iran. Tuberculosis has been diagnosed by gold standard tests like sputum culture, bronchoalveolar lavage (BAL) culture or cytology. For detection of HTLV-I antibody, Enzyme Linked Immunosorbant Assay method and western Blot as the confirming test were performed. Then 276 healthy cases were matched for gender and age. Results: The mean age of tuberculosis patients was 49.67±21.36 years and for control cases was 48.36±20.74. In patients group, 114 (41.6%) were male, 160 (58.4%) were female and in controls 123 (44.6%) were male and 153 (55.4%) were female. Pulmonary tuberculosis was presented in 84.2% of the patients. The frequency of HTLV-1 was 2.9% and 3.3% in patients and controls, respectively.HTLV-I frequency was higher in male patients and it increased by age. Conclusion: Regarding to this study, HTLV-I infection is not stand-alone sufficient for increasing the risk of tuberculosis. UR - https://jctm.mums.ac.ir/article_2608.html L1 - https://jctm.mums.ac.ir/article_2608_d2b1f21c89fd25203c0cf14073f30de8.pdf ER -