TY - JOUR ID - 9232 TI - The Relationship between Serum Uric Acid and Severity of Chronic Obstructive Pulmonary Disease (COPD) JO - Journal of Cardio-Thoracic Medicine JA - JCTM LA - en SN - 2345-2447 AU - Vafaei, Atefe AU - Saremi, Zeinab AU - Mortazavi Moghaddam, Sayyed Gholamreza AU - Javid Arabshahi, Zahra AD - Medical Student, Department of Internal Medicine, Birjand University of Medical Sciences, Birjand, Iran AD - Internal Medicine, Department of Internal Medicine, Birjand University of Medical Sciences, Birjand, Iran AD - Fellowship of Internal Medicine, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad,Iran Y1 - 2017 PY - 2017 VL - 5 IS - 3 SP - 181 EP - 186 KW - Chronic Obstructive Pulmonary Disease KW - Mortality KW - Outcome KW - Uric acid DO - 10.22038/jctm.2017.23869.1134 N2 - Introduction: Some evidence exists about the possible relationship between the serum uric acid (UA) and exacerbation of the chronic obstructive pulmonary disease (COPD). Present study intended to compare the COPD-related variables and the one-year outcome between the two groups of patients with the high and low UA. Material and Methods: This cohort study consisted of 112 patients with COPD exacerbation. The participants were categorized into low (i.e., Afterwards, the patients were followed up for one year and some other variables such as taking oral antibiotic for respiratory infections, admission to hospital or ICU due to COPD exacerbation, and survival were documented monthly. Results: The mean serum level of creatinine was significantly higher in the high UA group (1.1±0.4 mg/dL) than the low UA group (1.01±0.1 mg/dL) (P=0.02). No significant difference was observed between the two groups regarding the GOLD classification, FEV1, oxygen saturation, pCO2, and echocardiographic indices. In the one-year follow-up, 42 cases (82.4%) of the high UA group and 39 patients (63.9%) of the low UA group reported taking oral antibiotics, which was indicative of a significant difference (P=0.03). Hospital admission was likewise significantly higher in the high UA group (30 patients, 58.8%) than in the low UA group (23 cases, 37.7%) (P= 0.03). Conclusion: Those patients with the UA level of ≥ 6.5 mg/dL experienced more hospital admission and were more likely to take oral antibiotics for respiratory infections during a year. However, UA did not correlate with FEV1 or COPD severity. UR - https://jctm.mums.ac.ir/article_9232.html L1 - https://jctm.mums.ac.ir/article_9232_ba60f425751218a69067c951751b9de6.pdf ER -