A very rare case of metachronous multicentric giant cell tumor of bone with benign lung metastasis in form of a very large mass lesion

Document Type: Case Report

Authors

1 Respiratory Medicine, Department Of Respiratory Medicine, Jaslok Hospital And Research Center, Edarm (Ers),Idccm, Fnab, Edic, Fccp

2 Respiratory Medicine, Department Of Respiratory Medicine, Jaslok Hospital And Research Center, India

3 Nuclear Medicine, Department Of Nuclear Medicine, Jaslok Hospital And Research Centre, India

4 Nuclear Medicine, Department Of Nuclear Medicine, Jaslok Hospital And Research Center, India

5 Oncologist, Department of Medical Oncology,Jaslok Hospital And Research Center, India

Abstract

Giant cell tumour (GCT) is a benign, locally aggressive tumour of the bone that accounts for 5% of primary bone tumours and 21% of benign bone tumours. This tumour more commonly presents as a single (solitary) lesion; however, it may appear with multiple (multicentric) lesions in less than 1% of the cases. According to the literature, 1-9% of solitary GCTs metastasizes to the lung, more commonly in cases with local recurrence. There are limited case reports on multicentric GCT (MCGCT) in the literature. The MCGCT can be synchronous or metachronous depending upon the time interval between the two lesions. Herein, we presented a very rare case of metachronous MCGCT with benign lung metastasis in form of a huge lung mass.

Keywords


  1. Siebenrock KA, Unni KK, Rock MG: Giant-cell tumor of bone metastasising to the lungs: a long-term follow-up. J Bone Joint Surg (Br) 1998, 80:43–47.
  2. Dominkus M, Ruggieri P, Bertoni F, Briccoli A, Picci P, Rocca M, Mercuri M: Histologically verified lung metastases in benign giant cell tumours-1 cases from a single institution. IntOrthop 2006, 30:499–504.
  3. Muheremu A, Niu X. Pulmonary metastasis of giant cell tumor of bones. World Journal of Surgical Oncology. 2014; 12:261.
  4. Viswanathan S, Jambhekar NA: Metastatic giant cell tumor of bone: are there associated factors and best treatment modalities? ClinOrthopRelat Res 2010, 468:827–833
  5. Dhillon MS, Prasad P. Multicentric giant cell tumor of bone. Acta Orthop Belg 2007;73:289-99.
  6. Hoch B, Inwards C, Sundaram M, Rosenberg AE. Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirtycases. J Bone Joint Surg Am 2006; 88: 1998-2008.
  7. Park IH, Jeon IH. Multicentric giant cell tumor of bone: ten lesions at presentation. Skeletal Radiol 2003;32:526-9
  8. Rock MG: Curettage of giant-cell tumor of bone: factor influencing local recurrences and metastasis. ChirOrganiMov 1990, 75(Suppl. 1):204–205.
  9.  9.      Bosi T C C,Andrade1 F C G, Turtelli C M T, Ribeiro Júnior H A, Fatureto M C, Etchebehere R M. Lung metastasis of benign giant cell tumor: a case report.Radiol Bras [online]. 2008; 41(3): 207-209.
  10. Ozkan C, KalaciaA,Ozbarlas S. Giant-Cell Tumor of Bone with Pulmonary Metastases :Treatment by Combination of Chemotherapy and Whole-Lung Radiotherapy. Fırat Tıp Dergisi 2007;12(4): 306-310
  11. Tepeoglu M, Ozdemir B H. Pulmonary Metastasis of Benign Giant Cell Tumour of Bone Diagnosed By Fine-Needle Aspiration Cytology. Erciyes Med J 2013; 35(3): 167-70 • DOI: 10.5152/etd.2013.27
  12. Boghani A, Gayathri K, Ratnakar KS. Endobronchial metastasis from giant cell tumor of bone. Chest 1994; 106:1599‑601.
  13. Gupta SS, Kumar N, Mehrotra B. Endobronchial metastasis in benign giant cell tumor of bone in a 25-year male -Second case report with literature review. Lung India : Official Organ of Indian Chest Society. 2015; 32(4):409-410.
  14. Tandra VS, Kotha KMR, Satyanarayana MGV, Vadlamani KV, Yerravalli V. Synchronous Multicentric Giant Cell Tumor of Distal Radius and Sacrum with Pulmonary Metastases.Case Rep Oncol Med, 2015:354158.
  15. Naam NH, Jones SL, Floyd J, et al. Multicentric giant cell tumor of the fourth and fifth metacarpals with lung metastases. Hand (N Y) 2014;9:389–392
  16. Strauss LG, Dimitrakopoulou-Strauss A, Koczan D, Bernd L, Haberkorn U, Ewerbeck V, et al. 18F-FDG kinetics and gene expression in giant cell tumors. J Nucl Med. 2004;45:1528–3.
  17. Tubbs WS, Brown LR, Beabout JW, Rock MG, Unni KK: Benign giant-cell tumor of bone with pulmonary metastases: clinical findings and radiologic appearance of metastases in 13 cases. AJR Am J Roentgenol 1992, 158:331–334.
  18. US Food and Drug Administration FDA approves Xgeva to treat giant cell tumor of the bone. 2013. [Accessed May 5, 2015]. Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm356528.htm
  19. Akaike K, Suehara Y, Takagi T, Kaneko K and Saito T: An eggshell‑like mineralized recurrent lesion in the popliteal region after treatment of giant cell tumor of the bone with denosumab. Skeletal Radiol 43: 1767‑1772, 2014