Off-Pump Versus On-Pump Coronary Artery Bypass Graft Surgery, prospective cohort study

Document Type : Research Paper

Authors

1 Cardiac Surgeon, Department of Cardiac Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.

2 CardiacSurgeon, Department of Cardiac Surgery, Faculty of Medical Science, Farshchian Heart Center, Hamedan University of Medical Sciences, Hamedan, Iran

3 General Physician, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

5 Resident of Cardiac Surgery, Department of cardiac surgery, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Coronary artery bypass grafting is a surgical operation that bypasses atherosclerotic coronary vessels and restores blood flow to the ischemic zone of hearts. And two different conventional methods are ON-pump CABG, and Off-pump CABG.  Altogether, the efficacy and safety of these two types of surgical procedures are still under debate. In this study, we aim to compare the efficacy, safety, and cost-effectiveness of these two different methods in admitted patients to Imam Reza Hospital in Mashhad in Iran during 2006 to 2016.
Materials and Method: In this prospective cohort study, 533 patients who underwent CABG in Imam Reza hospital in Mashhad during 2006 to 2016 were identified. The data was collected using hospital records including demographic data, chief complaint, history of previous disease, ejection fraction, number of graft, blood transfusion, time of anesthesia, time of surgery, days of hospitalization, days of ICU stay, needs for reoperation, post-operative complication, expenses of hospitalization.
Results: Of 533 patients were 347 patients of whom male. The mean age was 59.53±10.21 and the mean BMI was 26.38±5.4. The most common chief complaint of the patients was chest pain. 38 patients of 533 cases underwent on-pump surgery and 495 underwent off-pump technique. There were no significant differences for age, and gender. The prevalence of HTN, diabetes, MI, and hyperlipidemia had no differences among two groups. Renal failure was more common in on-pump group; whereas, pulmonary disease was more common in off-pump group. On-pump surgery required significantly longer hospitalization and ICU care. Also needs for reoperation was more common among on-pump surgery. Total expenses were significantly higher in on-pump group.10.5% of those who underwent on-pump surgery died after surgery. This rate was only 3.1% among off-pump group.
Conclusion: In this study we showed that, the patients who underwent on-pump surgery, required longer hospitalization, and ICU care. Total expenses were significantly higher in on-pump group. In addition, the mortality rate of on-pump group was significantly higher than the off-pump group. Also needs for reoperation was more common among on-pump surgery. Altogether, it seems that off-pump surgery is safer with low expenses than on-pump CABG.

Keywords


1.             Bachar BJ, Manna B. Coronary Artery Bypass Graft.  StatPearls. Treasure Island (FL): StatPearls Publishing
StatPearls Publishing LLC.; 2019.
2.             Shroyer AL, Grover FL, Hattler B, Collins JF, McDonald GO, Kozora E, et al. On-pump versus off-pump coronary-artery bypass surgery. The New England journal of medicine. 2009;361(19):1827-37.
3.             Kim HJ, Chung JE, Jung JS, Kim IS, Son HS. Current Status of Off-pump Coronary Artery Bypass Grafting in Patients with Multiple Coronary Artery Disease Compared with On-pump Coronary Artery Bypass Grafting: The Korean National Cohort Study. The Thoracic and cardiovascular surgeon. 2018;66(6):470-6.
4.             Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Straka Z, et al. Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting. 2016;375(24):2359-68.
5.             Hueb W, Rezende PC, Gersh BJ, Soares PR, Favarato D, Lima EG, et al. Ten-Year Follow-Up of Off-Pump and On-Pump Multivessel Coronary Artery Bypass Grafting: MASS III. Angiology. 2019;70(4):337-44.
6.             Amouzeshi A, Amouzeshi Z, Teshnizi MA, Moeinipour AA, Maleki MHJAMI. Off-Pump Versus On-Pump Coronary Artery Bypass Graft Surgery Outcomes During 6 Years: A Prospective Cohort Study. 2017:578-84.
7.             Straka Z, Widimsky P, Jirasek K, Stros P, Votava J, Vanek T, et al. Off-pump versus on-pump coronary surgery: final results from a prospective randomized study Prague-4. The Annals of Thoracic Surgery. 2004;77(3):789-93.
8.             Velioglu Y, Isik M. Early-Term Outcomes of Off-Pump versus On-Pump Beating-Heart Coronary Artery Bypass Surgery. The Thoracic and cardiovascular surgeon. 2019.
9.             Le Bivic L, Magne J, Blossier JD, Piccardo A, Wojtyna H, Lacroix P, et al. Mid- and long-term prognosis of off- vs. on-pump coronary artery bypass graft in patients with multisite artery disease. The Journal of cardiovascular surgery. 2019;60(3):388-95.
10.          Scott BH, Seifert FC, Grimson R, Glass PS. Resource utilization in on- and off-pump coronary artery surgery: factors influencing postoperative length of stay--an experience of 1,746 consecutive patients undergoing fast-track cardiac anesthesia. Journal of cardiothoracic and vascular anesthesia. 2005;19(1):26-31.
11.          Takagi H, Hari Y, Mitta S, Kawai N, Ando T. A meta-analysis of >/=5-year mortality in randomized controlled trials of off-pump versus on-pump coronary artery bypass grafting. Journal of cardiac surgery. 2018;33(11):716-24.
12.          Zhang B, Zhou J, Li H, Liu Z, Chen A, Zhao QJTAots. Comparison of graft patency between off-pump and on-pump coronary artery bypass grafting: an updated meta-analysis. 2014;97(4):1335-41.
13.          Afilalo J, Rasti M, Ohayon SM, Shimony A, Eisenberg MJJEhj. Off-pump vs. on-pump coronary artery bypass surgery: an updated meta-analysis and meta-regression of randomized trials. 2011;33(10):1257-67.