The Lipid Profile Parameter in Chronic Obstructive Pulmonary Disease Patients and Correlation with Severity of Disease

Document Type: Original Article


1 Pulmonologist, Department of Respiratory Medicine, Modern Institute of Medical Sciences, Indore, India

2 Pulmonologist, Department of Respiratory Medicine, Sri Aurobindo Institute of Medical Sciences and Pg Institute, Indore, India


Introduction: More than 90% of the deaths caused by chronic obstructive pulmonary disease (COPD) occur in the low- and middle -income countries. The main aim of this study was to investigate the lipid profile levels in COPD patients and examine the correlation of total cholesterol, triglycerides, low-density lipoproteins, high density lipoproteins, and LDL/HDL risk ratio with COPD stages that are developed by the global initiative for chronic obstructive lung disease (GOLD)
Materials & Methods: A total of 100 COPD patients including 25 COPD non-smokers were enrolled in this study. The diagnosis of COPD was carried out by using the spirometry following the GOLD guidelines (post-bronchodilator forced expiratory volume (FEV1)/forced vital capacity (FVC) ratio < 70% predicted). Accordingly, the patients were divided into four groups based on the severity of their disease in accordance with the GOLD guidelines, including mild COPD (stage I, FEV1 ≥ 80% predicted), moderate COPD (stage II, 50% ≤ FEV1 < 80% predicted), severe COPD (stage III, 30% ≤ FEV1 < 50% predicted), and very severe COPD (stage IV, FEV1 < 30% predicted). The fasting blood samples of lipid profile were collected. The four COPD groups were compared using the ANOVA test.
Results: According to the results, the majority 53 patients (53%) were in age group 40 to 60 years with mean age of 60.46 +/-11.56. Most of the patients had moderate to severe airflow obstruction (GOLD stages II and III). The severity of COPD had no significant correlation with the triglycerides, LDL, HDL, and LDL/HDL risk ratio. The mean total cholesterol levels in the stages I and IV were 151.92±32.82 and 128.50 ±21.46 mg/dL, respectively, which was statistically significant (P=0.04).
Conclusion: The present study indicates that there was no significant correlation between various lipid profile parameters and severity of COPD.


  1.  Senior RM, Anthonisen NR. Chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 1998; 157:S139-47.
  2. Barnes PJ. Chronic obstructive pulmonary disease: effects beyond the lungs. PLoS Med. 2010; 7:1-4.
  3. Watz H, Waschki B, Kirsten A, Muller KC, Kretschmar G, Meyer T, et al. The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivity. Chest. 2009; 136:1039–46.
  4. Chatila WM, Thomashow BM, Minai OA, Criner GJ, Make BJ. Comorbidities in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008; 4:549–55.
  5. Rao MV, Raghu SR, Kiran SP, Rao CH. A study of lipid profile in chronic obstructive pulmonary disease. J Evolut Med Dental Sci. 2015; 4:7287-96.
  6. Sin DD, Man SF. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation. 2003; 107:1514-9.
  7. Martin SS, Blaha MJ, Elshazly MB, Toth PP, Kwiterovich PO, Blumenthal RS, et al. Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile. JAMA. 2013; 19:2061–8.
  8. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012; 176:532-5.
  9. de Lucas-Ramos P, Izquierdo-Alonso JL, Rodriguez-Gonzalez Moro JM, Frances JF, Lozano PV, Bellón-Cano JM, et al. Chronic obstructive pulmonary disease as a cardiovascular risk factor. Results of a case-control study (CONSISTE study). Int J Chron Obstruct Pulmon Dis. 2012; 7:679-86.
  10. Zafirova-Ivanovska B, Stojkovikj J, Dokikj D, Anastasova S, Debresliovska A, Zejnel S, et al. The level of cholesterol in COPD patients with severe and very severe stage of the disease. Open Access Maced J Med Sci. 2016; 2:277-82.
  11. Caram LM, Ferrari R, Naves CR, Coelho LS, Vale SA, Tanni SE, et al. Risk factors for cardiovascular disease in patients with COPD: mild-to-moderate COPD versus severe-to-very severe COPD. J Bras Pneumol. 2016; 3:179-84.
  12. Niranjan MR, Dadapeer K, Rashmi K. Lipoprotein profile in patients with chronic obstructive pulmonary disease in a tertiary care hospital in South India. J Clin Diagn Res. 2011; 5:990-3.
  13. Begum K, Begum MK, Sarke ZH, Dewan MR, Siddique MJ. Lipid profile status of chronic obstructive pulmonary disease in hospitalized patients. Bangladesh J Med Biochem. 2010; 2:42-5.