VKORC1 AND CYP2C9 GENETIC VARIANTS CUMARIN RESPONSE IN MESTIZO-MEXICANS POPULATION

Articles in Press

Document Type : Original Article

Authors

1 AV FELIX CUEVAS 540

2 AV FELIX CUEVAS 5540

10.22038/jctm.2025.92185.1516

Abstract

Polymorphism as genetic variations in VKORC1 and CYP2C9 have shown variability in anticoagulant response in several ethnic groups. In Mestizo-Mexican population, considering their Amerindian-European and African-Asiatic ancestral origins, response also would be different. We evaluated the anticoagulant response to coumarin in Mestizo-Mexican patients with mechanical heart valve prostheses.

Method

The DNA was extracted from a blood sample using a commercial genomic DNA purification kit. The polymorphism rs1799853 CT CYP2C9*2 gene and rs9923231VKORC1-G1639A gene were determined with real-time PCR. All patients received 8 mg/day initial coumarin doses and after was adjusted at second day according to INR until reach 2.5-3.5 result.

Results

Seventy-six patients aged 58±11 years were undergoing mitral (n=44) and aortic (n=32) valve replacement. To reach therapeutic range, coumarin dose was significantly higher in patients carrying GG haplotypes in rs9923231VKORC1-G1639A gene variant (p=0.001) compared to GA and AA haplotypes. The rs1799853 polymorphism of the CYP2C9*2 A/C gene showed no differences between AA, AC, and CC haplotypes (p>0.05).

Conclusion

In Mestizo-Mexican population with polymorphism rs9923231-VKORC1 gene carriers, GG haplotype has hyporeactive anticoagulant response compared with GA with normal, and AA with hyperreactive response, without differences in response of polymorphisms CYP2C9*2 haplotypes AC carriers.

Keywords

Journal of Cardio-Thoracic Medicine

Articles in Press, Accepted Manuscript
Available Online from 16 December 2025

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