TY - JOUR ID - 21216 TI - Age-Specific Reference Intervals for Routine Laboratory Biochemical Tests in The Iranian Adolescent Girls JO - Journal of Cardio-Thoracic Medicine JA - JCTM LA - en SN - 2345-2447 AU - Pashirzad, Mehran AU - Ghazizadeh, Hamideh AU - Seddigh Shamsi, Mohsen AU - Yaghooti-Khorasani, Mahdiyeh AU - Assaran Darban, Reza AU - Kamel Khodabandeh, Atieh AU - Akbarpour Bahre, Ensieh AU - Mohammadi Bajgiran, Maryam AU - Mansouri, Amin AU - Javid Dash Bayyaz, Reza AU - Asadian, Parisa AU - Khanizadeh, Khashayar AU - Akhtari, Hale AU - Hadizadeh, Melika AU - Babaei, Arvin AU - Khayatzadeh, Sayyed Saeid AU - Ferns, Gordon A. AU - Esmaily, Habibollah AU - Ghayour-Mobarhan, Majid AD - Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran. AD - Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran. AD - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran. AD - Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. Y1 - 2022 PY - 2022 VL - 10 IS - 4 SP - 1052 EP - 1064 KW - adolescent girls KW - Biochemical markers KW - CLSI guidelines KW - Reference intervals DO - 10.22038/jctm.2022.67858.1398 N2 - Introduction: For interpretation of the most common biochemical markers reference intervals (RIs) are widely considered and reported. Therefore, in this study, we aimed to determine age-specific RIs for some biochemical tests by removing and/or limiting critical gaps including sex, age group, geographical region, measurement device, and type of kits and reagents for routine laboratory biochemical variables in healthy adolescent girls aged 12-19 years.Materials and Methods:  In this cross-sectional study a total of 1026 adolescent girl was recruited. According to the study aim, the levels of serum for some routine biochemical tests were measured on a BT-3000 auto-analyzer. On the basis of the non-parametric rank method and by use of CLSI Ep28-A3 guidelines, we determined age-specific RIs, including confidence interval 90%, under specific exclusion criteria.Results: Age partitioning was required for none of the upper and lower limits of biochemical markers. All Serum biochemical tests concentration remained relatively constant throughout the age range. Conclusion: By removing and/or limiting critical gaps involved in reference values of biochemical tests, it has provided an important understanding of metabolic processes and it has facilitated clinical application to track different diseases better UR - https://jctm.mums.ac.ir/article_21216.html L1 - https://jctm.mums.ac.ir/article_21216_12830e94d978fb257aa9236a76035296.pdf ER -