<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Journal of Cardio-Thoracic Medicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://jctm.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2345-2447</journal_id_issn>
			<journal_id_issn_online>2322-5750</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<volume>14</volume>
			<number>1</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>VKORC1 and CYP2C9 Genetic Variants Coumarin Response in the Mestizo-Mexican Population</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Introduction: Polymorphisms in the genetic variations of vitamin K epoxide reductase complex subunit 1 (VKORC1) and Cytochrome P450 subfamily IIC polypeptide 9 (CYP2C9) have been shown to cause variability in anticoagulant response across various ethnic groups. In the Mestizo-Mexican population, with their Amerindian-European and African-Asiatic ancestral origins, the response is expected to differ as well. This study aims to evaluate the anticoagulant response to coumarin in Mestizo-Mexican patients with mechanical heart valve prostheses.Method: DNA was extracted from blood samples using a commercial genomic DNA purification kit. The polymorphisms rs1799853 CT in the CYP2C9*2 gene and rs9923231VKORC1-G1639A gene were determined using real-time PCR. All patients initially received a dose of 8 mg/day of coumarin, which was adjusted on the second day based on international normalized ratio (INR) levels until reaching a result of 2.5-3.5.Results : Seventy-six patients with an average age of 58±11 years were undergoing mitral (n=44) and aortic (n=32) valve replacement. Patients carrying GG haplotypes in the rs9923231VKORC1-G1639A gene variant required a significantly higher coumarin dose to reach the therapeutic range compared to those with GA and AA haplotypes (p=0.001). The rs1799853 polymorphism of the CYP2C9*2 A/C gene showed no significant differences between AA, AC, and CC haplotypes (p&gt;0.05).Conclusion : In the Mestizo-Mexican population, individuals carrying the rs9923231 VKORC1 gene with GG haplotypes exhibited a hyporeactive anticoagulant response compared to those with GA and AA haplotypes, which showed normal and hyperreactive responses, respectively. There were no significant differences in the response of the CYP2C9*2 haplotypes AC carriers.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Coumarin anticoagulation, Mestizo-Mexican population, VIKORC1 &amp; CYP2C9*2 genetic variants</keyword>
				<start_page>1662</start_page>
				<end_page>1667</end_page>
				<web_url>https://jctm.mums.ac.ir/article_27173.html</web_url>
			<author_list><author>
				<first_name>José</first_name>
				<middle_name>Luis</middle_name>
				<last_name>Aceves Chimal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aceves996@hotmail.com</email>
				<code>119356</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Cardiothoracic Surgeon, Cardiovascular Department, CMN 20 de Noviembre, ISSSTE. México City.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Guillermo</first_name>
				<middle_name></middle_name>
				<last_name>Díaz Quiroz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gdiazquiroz@yahoo.com.mx</email>
				<code>119357</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cardiothoracic Surgeon, Cardiovascular Department, CMN 20 de Noviembre, ISSSTE. México City.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mónica</first_name>
				<middle_name></middle_name>
				<last_name>Escamilla Tilch</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>monica.escamilla@issste.gob.mx</email>
				<code>119358</code>
				<coreauthor>No</coreauthor>
				<affiliation>Science Research Doctor, Biomedical Research Department, CMN 20 de Noviembre ISSSTE, México City.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Silvia</first_name>
				<middle_name></middle_name>
				<last_name>Cortes Martínez</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>silvia1830@hotmail.com</email>
				<code>119359</code>
				<coreauthor>No</coreauthor>
				<affiliation>Pharmacobiological Chemistryc, Hormons Laboratory, CMN 20 de Noviembre ISSSTE, México City.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>