Relationship between Neutrophil-to-lymphocyte Ratio and the Severity of Coronary Artery Disease in Patients Undergoing Cardiac Catheterization

Document Type : Original Article


1 Cardiologist, Department of Cardiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran

2 General Practitioner, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3 General Practitioner, Student Research Committee, School of Medicine, Qom University of Medical Sciences, Qom, Iran

4 Community Medicine Specialist, Department of Community Medicine, Spiritual Health Research Center, Qom University of Medical Sciences, Qom, Iran


Introduction: Neutrophil-to-lymphocyte ratio (NLR) is considered as an independent predictor of long-term prognosis in the individual patients with coronary artery disease (CAD). This study sought to assess the relationship between NLR and CAD severity in Iranian patients undergoing cardiac catheterization.
Material and Methods: This prospective study was conducted on 500 patients with acute coronary syndrome (ACS) presented to Shahid Beheshti Hospital, Qom, Iran, for admission and underwent cardiac catheterization between March 2015 and May 2017. The patients were assigned into three groups of high NLR (more than 3), intermediate NLR (between 2 and 3), and low NLR (less than 2). Then the CAD severity and its relationship with NLR were assessed.
Results: According to the results, there was a significant difference between the groups in terms of CAD severity (P<0.001), and high NLR was independently associated with more severe CAD.
Conclusion: Given the results of this study, high NLR was associated with CAD severity.


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