Serum vitamin D level and hypertensive crises

Document Type : Original Article


1 Cardiologist, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, School of Health, Kerman University of Medical Sciences, Kerman, Iran

2 Resident of cardiology, Clinical Research Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

3 Community medicine, Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran


Introduction :Vitamin D deficiency is associated with hypertension; however, there is no study on the relationship between vitamin D deficiency and hypertensive crises. This study aimed to determine the relationship between serum vitamin D levels and hypertensive crises.
Materials and Methods: This descriptive-analytical, cross-sectional study was conducted on 120 individuals in Shafa Hospital in 2016 within the age range of 40-80 years, selected through simple random sampling technique. The research population was divided into two groups of hypertensive crises (n=60) with blood pressure over 180/120 mm/Hg and hypertensive patients without history of hypertension crises (n=60). For the purpose of the study, 5 ml peripheral venous blood samples were collected. The blood serum was isolated by a centrifugal device, and the serum vitamin D levels were analyzed by radioimmunoassay.
Results: The meanlevels ofvitamin D in hypertensive and non- hypertensive crises groups were 29.73 and 30.23 ng/ml, respectively. There was no significant difference between the two groups in terms of vitamin D levels (P>0.05). However, no statistically significant difference was observed between the two groups considering gender (P>0.05). Serum vitamin D levels showed a direct correlationwith theduration of hypertension and age (P Conclusion:There is evidence on the relationship between serum vitamin D levels and cardiovascular diseases, including hypertension. Nonetheless, in the present study, no significant relationship was observed between serum vitamin D level and hypertensive crises.


1- Varon J. The diagnosis and treatment of hypertensive crises. Postgraduate medicine. 2009 Jan 1;121(1):5-13.
2- Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The 6th Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med. 1997; 157:2413-2446
3- Bakaeean B, Kabiri M, Iranfar H, Saberi MR, Chamani J. Binding effect of common ions to human serum albumin in the presence of norfloxacin: investigation with spectroscopic and zeta potential approaches. Journal of Solution Chemistry 2012; 41(10): 1777-1801.
4- Laragh J. Laragh's lessons in pathophysiology and clinical pearls for treating hypertension. AJH. 2001; 14:837-854.
5- Rodriguez MA, Kumar SK, De caro M. Hypertensive crisis. Cardiology in review. 2010; 18:102-107.
6- Aalami S, Nikoui V, Irani M, Bakhtiarian A. Plasma zinc levels in normotensive and hypertensive adults: a comparative study in Tehran Heart Center. TUMJ. 2012; 70:416-422.(Persian)
7- Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr. 2007; 85:860-868.
8- Hamed-Akbari Tousi Sh, Saberi MR, Chamani J. Comparing the Interaction of cyclophosphamide monohydrate to human serum albumin as opposed to holo-transferrin by spectroscopic and molecular modeling methods: evidence for allocating the binding site. Protein and peptide Letters. 2010; 17(12): 1524-35.
9- Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, et al.1, 25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter.J Biol Chem. 2007;282:29821-29830.
10- Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006; 83:754-759.
11- Rashidipour S, Naeeminejad S, Chamani J. Study of the interaction between DNP and DIDS with human hemoglobin as binary and ternary systems: spectroscopic and molecular modeling investigation. Journal of Biomolecular Structure and Dynamics. 2016; 34 (1): 57-77.
12- Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008; 168:1629-1637.
13- Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, et al. Independent association of low serum 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008; 168:1340-1349.
14-Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. AJH. 2007; 20:713-719.
15- Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V. Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 2008; 87:136-141.
16- Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007; 167:1159-1165.
17- Hintzpeter B, Mensink GB, Thierfelder W, Müller MJ, Scheidt-Nave C. Vitamin D status and health correlates among German adults. Eur J Clin Nutr. 2008; 62:1079-1089.
18- Ghaderabad M, Mansouri M, Beigoli S, Sharifi Rad A, Mehrzad J, Saberi MR, Chamani J. A comparison of the inclusion behavior of human serum albumin and holo transferrin with fluoxymesterone in the presence of three different cyclodextrins. Journal of the Iranian Chemical Society. 2017; 14 (7): 1347-1364.
19- Wang Y, Wang QJ. The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines: new challenges of the old problem. Arch Intern Med. 2004; 164:2126-2134.
20- Margolis KL, Ray RM, Van Horn L, Manson JE, Allison MA, Black HR, et al. Effect of calcium and vitamin D supplementation on blood pressure: The Women’s Health Initiative Randomized Trial. Hypertension. 2008; 52:847-855.
21- Li L, Yin X, Yao C, Zhu X, Wu X. Vitamin D, parathyroid hormone and their associations with hypertension in a Chinese population. PloS one. 2012;7: e43344.
22-Chan R, Chan D, Woo J, Ohlsson C, Mellström D, Kwok T, et al. Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men. J Hum Hypertens. 2012; 26:20-27.
23- Shin JH, Lee HT, Lim YH, Park HC, Shin J, Kim Kismet Al. Defining Vitamin D Deficiency and its Relationship to Hypertension in Postmenopausal Korean Women. J Womens Health. 2015;24: 1021-1029.
24- Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short-term vitamin D (3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001; 86:1633–1637.
25- Forman JP, Bischoff-Ferrari HA, Willett WC, Stampfer MJ, Curhan GC. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension. 2005; 46:676-682.
26- Arora P, Song Y, Dusek J, Plotnikoff G, Sabatine MS, Cheng S, et al. Vitamin D therapy in individuals with prehypertension or hypertension: The DAYLIGHT trial. Circulation. 2015; 131:254–262.
27- Kim MK, Il Kang M, Won Oh K, Kwon HS, Lee JH, Lee WC,et al. The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle‚Äźaged Korean subjects. Clin Endocrinol. 2010; 73:330-338.
28- Witham MD, Nadir MA, Struthers AD. Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J Hypertens. 2009; 27:1948-1954.
29- Mehta V, Agarwal S. Does vitamin D deficiency lead to hypertension?. Cureus. 2017;9:e1038.
30- Jeong HY, Park KM, Lee MJ, Yang DH, Kim SH, Lee SY. Vitamin D and hypertension. Electrolytes & Blood Pressure. 2017; 15:1-11.