Rare Presentation of Sarcoidosis

Document Type : Case Report

Authors

1 Pulmonologist, Department of Pulmonary Medicine, HIMS, Jollygrant, Dehradun, Indian.

2 Pathologist, Department of Pathology, HIMS, Jollygrant, Dehradun, Indian

3 Radiologist, Department of Radiodiagnosis, HIMS, Jollygrant, Dehradun, Indian

Abstract

Sarcoidosis is an idiopathic, noncaseating granulomatous disorder with wide systemic involvement. Lungs, eyes, and skin are the organs most commonly affected. Bone involvement, which is very rare, was reported as present in 3 to 13% of affected cases. Here we present a case of young female with ribs, vertebrae and pulmonary involvement, lesion mimicking as metastasis or tuberculosis thus emphasizing the importance of differential diagnosis.

Keywords


  1. Iannuzzi MC, Rybicki BA, Teirstein AS, Sarcoidosis N. Engl. J Med. 2007;357:2153-65.
  2. Newman LS, Rose CS, Bresnitz EA, Rossman MD, Barnard J, Frederick M, Terrin ML, Weinberger SE, Moller DR, McLennan G, Hunninghake G. A case control etiologic study of sarcoidosis: environmental and occupational risk factors. American journal of respiratory and critical care medicine. 2004 Dec 15;170(12):1324-30.
  3. O'Daly BJ, Harty JA, O'Malley N, Killeen R, McDonnell TJ, Quinlan WR. Bilateral olecranon fracture as first presentation of sarcoidosis: case report and review of the literature. Journal of shoulder and elbow surgery. 2008 Jul 1;17(4):e1-5.
  4. Haddad N, Oliveira Filho JD, Nasser KD, Corbett AM, Tebet AC, Reis ML. Musculoskeletal and cutaneous sarcoidosis: exuberant case report. Anais brasileiros de dermatologia. 2014 Aug;89(4):660-2.
  5. Greer EL, Banko MR, Brunet A. AMP-activated protein kinase and FoxO transcription factors in dietary restriction–induced longevity. Annals of the New York Academy of Sciences. 2009 Jul; 1170:688.
  6. Packer CD, Mileti LM. Vertebral sarcoidosis mimicking lytic osseous metastases: development 16 years after apparent resolution of thoracic sarcoidosis. JCR: Journal of Clinical Rheumatology. 2005 Apr 1;11(2):105-8.
  7. Sweiss NJ, Lower EE, Korsten P, Niewold TB, Favus MJ, Baughman RP. Bone health issues in sarcoidosis. Current rheumatology reports. 2011 Jun 1;13(3):265-72.
  8. Salari M, Rezaieyazdi Z. Prevalence and clinical picture of musculoskeletal sarcoidosis. Iranian Red Crescent Medical Journal. 2014 Jul;16(7).
  9.   Delghandi, M., Rezaeetalab, F., Ebrahimzadeh, F., Najaf Najafi, M. Investigation serum procalcitonin in patients with   exacerbation of obstructive pulmonary disease. Journal of Cardio-Thoracic Medicine, 2020; 8(4): 700-706.
  10. Chamani J. Energetic domains analysis of bovine α-lactalbumin upon interaction with copper and dodecyl trimethylammonium bromide. Journal of Molecular Structure. 2010;979(1-3):227-234.
  11. Gupta SK, Mitra K, Chatterjee S, Chakravarty SC. Sarcoidosis in India. Br J Dis Chest. 1985;79(C):275–83.
  12. Sharma SK, Mohan A. Sarcoidosis in India: not so rare. Journal, Indian Academy of Clinical Medicine. 2004;5(1):12-21.
  13. Mootha VK, Agarwal R, Aggarwal AN, Gupta D, Ahmed J, Verma I, Bal A. The Sarcoid–Tuberculosis link: evidence from a high TB prevalence country. Journal of Infection. 2010 Jun 1;60(6):501-3.
  14. Kemah B, Özturan B, Bilgic B, Özkan K, Akpınar F, Kılıc B. An Unusual Orthopaedic Disease: Sarcoidosis—A Case Report. The Surgery Journal. 2017 Apr;3(2):e75.
  15. Jansen TL, Geusens PP. Sarcoidosis: joint, muscle and bone involvement. European Respiratory Monograph. 2005 Sep 1;32:210.