Journal of Cardio-Thoracic Medicine

Journal of Cardio-Thoracic Medicine

Inflammatory and Tissue Damage Biomarkers Progression as Mortality Prognosis in Patients with Covid-19 Disease

Document Type : Original Article

Authors
Monica Escamilla Tilch 1
Lourdes Lilian López Dawn 2
Adriana Balderrama 3
Francisco Ramírez Bernal 4
Brigney Aceves Poveda 4
Guillermo Díaz Quiroz 2
Alberto De la Vega 4
Paul Mondragón-Terán 5
José Luis Aceves Chimal 2
1 Science Research Doctor, Biomedical Research Department, CMN 20 de Noviembre ISSSTE, México City.
2 Cardiothoracic Surgeon, Cardiovascular Department, CMN 20 de Noviembre ISSSTE, México City.
3 Endocrinologist, Endocrinology Department, CMN 20 de Noviembre ISSSTE, México City.
4 Intensive Care Physician, Intensive Therapy Department, CMN 20 de Noviembre ISSSTE, México City.
5 Bio-medical Engineer, Research Coordination, CMN 20 de Noviembre ISSSTE, México City.
10.22038/jctm.2021.60678.1354
Abstract
Introduction: Metabolic and inflammatory disorders are widely described in COVID-19 disease by SARS-CoV-2, especially in advanced gravity stages, nevertheless, the increase in inflammatory and tissue damage biomarkers could identify patients with higher mortality risk since early disease stages.
Material and Method: A retrospective Cohort study was performed to evaluate the progression pattern and mortality risk of proinflammatory (Ferritin and IL-6) and damage tissue biomarkers seric levels (LDH, CPK, CPK-MB and TnIc) since the beginning of the disease to end outcome considered, in this study, as death or recovery
Results: We evaluated 120 patients with mean age 51±10 years. The CAT study showed in all patients bilateral polished glass lung lesions. The inflammatory and seric tissue injured biomarkers were significantly higher since the beginning of the hospitalization in patients who died compared with patients that survived (p = 0.01). The myocardial injury biomarkers (CPK-MB and TnIc) were significantly higher in severe gravity stages of deceased patients compared to patients who survived (p = 0.001 and 0.003 respectively) with a global mortality of 38.3% (n = 48). The mortality risk was extremely elevated (RR> 10) when inflammatory and tissue injury biomarkers showed seric levels 2 folds above normal values, showing survival of  < 60% after tenth day since the beginning disease.
Conclusion: Since the beginning of COVID-19 disease by SARS CoV2 virus, patients show serum elevation in ferritin, LDH and CPK. This seric values were associated with higher mortality risk, when elevated 2 folds above normal values.
Keywords
SARS-CoV-2
Covid-19
inflammatory Biomarkers
Tissue injury
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Journal of Cardio-Thoracic Medicine
Volume 9, Issue 4
Autumn 2021
Pages 878-883