Association of Serum Anti-Heat Shock Protein 27 Antibody with Obesity Risk among Healthy Individuals in MASHAD Study

Document Type : Original Article

Authors

1 Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

6 Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran.

7 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

8 Department of Medical Education, Brighton & Sussex Medical School, Brighton, BN1 9PH, UK.

Abstract

Introduction: The association between the serum antibody titer of several heat shock proteins (HSPs) and cardiovascular disease (CVD) risk factors so far has been the subject of several previous studies.
Aim: To evaluate the association of adiposity indices and HSP-27 antibody titers in healthy individuals.
Materials and Methods: Overall 4823 individuals were recruited from Mashhad Stroke and Heart Atherosclerotic Disorders Study (MASHAD study), that included 1496 individuals with normal-weight (body mass index (BMI) <25 kg/m2), 1975 individuals with over-weight (BMI 25-30 kg/m2), and 1352 individuals with obesity (BMI≥ 30 kg/m2).
Results: The serum anti-HSP-27 antibody titers were not significantly different among obese individuals [0.21 (0.11 – 0.34) absorbency unit (AU)], over-weight individuals [0.19 (0.10 – 0.33) AU] and normal-weight individuals [0.19 (0.10 – 0.33) AU].
Conclusions: we have found no significant relationship among anti-HSP-27 antibody concentration and degrees of adiposity among Iranian adults.

Keywords

References

  1. Ghayour-Mobarhan M, New SA, Lamb DJ, Starkey BJ, Livingstone C, Wang T, et al. Dietary antioxidants and fat are associated with plasma antibody titers to heat shock proteins 60, 65, and 70 in subjects with dyslipidemia. The American journal of clinical nutrition. 2005 May 1;81(5):998-1004.
  2. Martin JL, Hickey E, Weber LA, Dillmann WH, Mestril R. Influence of phosphorylation and oligomerization on the protective role of the small heat shock protein 27 in rat adult cardiomyocytes. Gene Expression The Journal of Liver Research. 1999 Jan 1;7(4-5):349-55.
  3. Pourghadamyari H, Moohebati M, Parizadeh SM, Falsoleiman H, Dehghani M, Fazlinezhad A, et al. Serum antibody titers against heat shock protein 27 are associated with the severity of coronary artery disease. Cell Stress and Chaperones. 2011 May;16(3):309-16.
  4. Pengiran Burut DF, Borai A, Livingstone C, Ferns G. Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study. Cell Stress and Chaperones. 2010 Jul;15(4):379-86.
  5. Ghayour-Mobarhan M, Rahsepar AA, Tavallaie S, Rahsepar S, Ferns GA. The potential role of heat shock proteins in cardiovascular disease: evidence from in vitro and in vivo studies. Advances in clinical chemistry. 2009 Jan 1;48:27-72.
  6. Ghayour‐Mobarhan M, Sahebkar A, Parizadeh SM, Moohebati M, Tavallaie S, RezaKazemi‐Bajestani SM, et al. Antibody titres to heat shock protein 27 are elevated in patients with acute coronary syndrome. International journal of experimental pathology. 2008 Jun;89(3):209-15.
  7. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circulation research. 2005 May 13;96(9):939-49.
  8. Ghayour-Mobarhan M, Moohebati M, Esmaily H, Ebrahimi M, Parizadeh SM, Heidari-Bakavoli AR, et al. Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation. International journal of public health. 2015 Jul;60(5):561-72.
  9. Azarpazhooh MR, Mobarra N, Parizadeh SM, Tavallaie S, Bagheri M, Rahsepar AA, et al. Serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with stroke and 6-month prognosis. Angiology. 2010 Aug;61(6):607-12.
  10. Xu Q, Wick G, Willeit J, Marosi M, Kiechl S, Luef G, et al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. The Lancet. 1993 Jan 30;341(8840):255-9.
  11. Yao Y, Watson AD, Ji S, Boström KI. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein. Circulation research. 2009 Sep 11;105(6):575-84.
  12. Kardys I, Rifai N, Meilhac O, Michel JB, Martin-Ventura JL, Buring JE, et al. Plasma concentration of heat shock protein 27 and risk of cardiovascular disease: a prospective, nested case-control study. Clinical chemistry. 2008 Jan 1;54(1):139-46.
  13. Shams S, Shafi S, Bodman-Smith K, Williams P, Mehta S, Ferns GA. Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. Clinica chimica acta. 2008 Sep 1;395(1-2):42-6.
  14. Vidyasagar A, Wilson NA, Djamali A. Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target. Fibrogenesis & tissue repair. 2012 Dec;5(1):1-7.
  15. Sadabadi F, Zirak RG, Ghazizadeh H, Moghadam AR, Mouhebati M, Ehyaei S, et al. Physical activity level (PAL) and risk factors of cardiovascular disease   in   the   MASHAD   study cohort. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021 Nov 1;15(6):102316.
  1. Tavana M, Ghazizadeh H, Sadeghzade M, Tavalaie S, Abolbashari S, Ramshini H, et al. Serum anti-hsp27 antibodies concentration in diabetes mellitus; population based case-control study. Archives of Medical Laboratory Sciences. 2019 Jan 1;5(1):12-7.
  2. Ragab SM, El-Hawy MA, Shehata AM, El-Shazly SM. The clinical significance of serum anti-heat-shock protein 27 antibody levels in β-thalassemia patients. Menoufia Medical Journal. 2017 Oct 1;30(4):1244.
  3. Sadabadi F, Heidari-Bakavoli A, Esmaily H, Darroudi S, Tayefi M, Asadi Z, et al. Is there any association between Serum anti-HSP27 antibody level and the presence of metabolic syndrome; population based case-control study. Revista Română de Medicină de Laborator Vol. 2019;27(2).
  4. Ghayour-Mobarhan M, Taylor A, Lamb DJ, Ferns GA. Association between indices of body mass and antibody titres to heat-shock protein-60,-65 and-70 in healthy Caucasians. International journal of obesity. 2007 Jan;31(1):197-200.
  5. Tavallaie S, Rahsepar AA, Abdi H, Moohebati M, Moodi F, Pourghadamyari H, et al. Association between indices of body mass and antibody titers to heat-shock protein-27 in healthy subjects. Clinical biochemistry. 2012 Jan 1;45(1-2):144-7.
  6. Kargari M, Tavassoli S, Avan A, Ebrahimi M, Azarpazhooh MR, Asoodeh R, et al. Relationship between serum anti-heat shock protein 27 antibody levels and obesity. Clinical Biochemistry. 2017 Aug 1;50(12):690-5.
Journal of Cardio-Thoracic Medicine
Volume 10, Issue 3
September 2022
Pages 1010-1016

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