Association of Serum Anti-Heat Shock Protein 27 Antibody with Obesity Risk among Healthy Individuals in MASHAD Study

Document Type : Original Article

Authors

1 Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

6 Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran.

7 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

8 Department of Medical Education, Brighton & Sussex Medical School, Brighton, BN1 9PH, UK.

Abstract

Introduction: The association between the serum antibody titer of several heat shock proteins (HSPs) and cardiovascular disease (CVD) risk factors so far has been the subject of several previous studies.
Aim: To evaluate the association of adiposity indices and HSP-27 antibody titers in healthy individuals.
Materials and Methods: Overall 4823 individuals were recruited from Mashhad Stroke and Heart Atherosclerotic Disorders Study (MASHAD study), that included 1496 individuals with normal-weight (body mass index (BMI) <25 kg/m2), 1975 individuals with over-weight (BMI 25-30 kg/m2), and 1352 individuals with obesity (BMI≥ 30 kg/m2).
Results: The serum anti-HSP-27 antibody titers were not significantly different among obese individuals [0.21 (0.11 – 0.34) absorbency unit (AU)], over-weight individuals [0.19 (0.10 – 0.33) AU] and normal-weight individuals [0.19 (0.10 – 0.33) AU].
Conclusions: we have found no significant relationship among anti-HSP-27 antibody concentration and degrees of adiposity among Iranian adults.

Keywords


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