Journal of Cardio-Thoracic Medicine

Journal of Cardio-Thoracic Medicine

A Case of Possible Motor-Sensory Symptoms Event Associated with SARS-Coronavirus-2

Document Type : Case Report

Authors
Sajjad Hoseinpour 1
Mahdie Aghaei 2
Malihe Aghasizadeh 3
Elahe Hasanzadeh 3
Mohsen Foroughipour 4
Majid Ghayour-Mobarhan 3
1 Department of Molecular Genetic, Medical laboratory, Imam Hosein Hospital, Mashhad, Iran.
2 Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
3 Iranian UNESCO Center of Excellence for Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Department of Neurology, Gaem Hospital, Mashhad Univeristy of Medical Sciences, Mashhad, Iran.
10.22038/jctm.2022.66313.1391
Abstract
A new infection emerged into the world which has been declared a global pandemic in December 2019, termed SARS-CoV-2 based on its first pulmonary manifestations. Also, Neurologic consequences can be disturbing complications of these respiratory viral diseases.
Here we present a 51-year-old nurse with motor-sensory symptoms following developed mild coryza symptoms including sore throat, general malaise, and conjunctivitis. However, a week of ocular muscle discomfort and weakness preceded coryza symptoms. She was returned negative by nasopharyngeal swab test twice for detection of the SARS-Cov-2 genome by a real-time polymerase chain reaction (PCR) and Chest X-Ray (CXR) examination. Since the patient had neurological symptoms, MRI was performed, which showed inflammation in the spinal cord and meninges.
Cerebrospinal fluid (CSF) fluid investigation for immunological and Covid-19 examination showed SARS-Cov-2 involvement in this patient. The patient's characteristics show that the involvement of Covid-19 is not limited to the lungs or gastrointestinal tract, and the nervous system, despite the presence of a brain barrier, can be invaded by the virus. From this point of view, we should expect a shadow of the involvement of different parts of the nervous system in Covid-19.
Keywords
CSF fluid
Neurologic
SARS-Coronavirus-2
  1. Covid CD, Team R, COVID C, Team R, Bialek S, Boundy E, et al. Severe outcomes among patients with coronavirus disease 2019 (COVID-19)—United States, February 12–March 16, 2020. Morbidity and mortality weekly report. 2020 Mar 27;69(12):343.
  2. Khadem-Rezaiyan M, Saberi-Karimian M, Kamel Khodabandeh A, Safarian-Bana H, Farkhani EM, Gholian M, et al. Estimating the Years of Life Lost and Mortality Caused By COVID-19 in Mashhad, the Second-Largest City in Iran. Journal of Nutrition, Fasting and Health. 2022 Mar 1;10(1):60-4.
  3. Saberi-Karimian M, Safarian-Bana H, Saffar S, Ghazizadeh H, Mousa Farkhani E, Mohammadi Bajgiran M, et al. Covid-19 Infection is Associated with Diabetes Mellitus in The MASHAD Cohort Study. Journal CardioThoracic Medicen. 2022;10(1):913-8.
  4. Ebrahimi M, Farhadian N, Amiri AR, Hataminia F, Soflaei SS, Karimi M. Evaluating the efficacy of extracted squalene from seed oil in the form of microemulsion for the treatment of COVID‐19: A clinical study. Journal of Medical Virology. 2022 Jan;94(1):119-30.
  5. Saberi-Karimian M, Khorasanchi Z, Ghazizadeh H, Tayefi M, Saffar S, Ferns GA, et al. Potential value and impact of data mining and machine learning in clinical diagnostics. Critical Reviews in Clinical Laboratory Sciences. 2021 May 19;58(4):275-96.
  6. Satarker S, Nampoothiri M. Involvement of the nervous system in COVID-19: The bell should toll in the brain. Life Sciences. 2020 Dec 1;262:118568.
  7. Lucchese G. Cerebrospinal fluid findings in COVID-19 indicate autoimmunity. The Lancet Microbe. 2020 Oct 1;1(6):e242.
  8. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients. Journal of medical virology. 2020 Jun;92(6):552-5.
  9. De Luca C, Colangelo AM, Virtuoso A, Alberghina L, Papa M. Neurons, glia, extracellular matrix and neurovascular unit: a systems biology approach to the complexity of synaptic plasticity in health and disease. International journal of molecular sciences. 2020 Feb 24;21(4):1539.
  10. Shirato K, Nao N, Katano H, Takayama I, Saito S, Kato F, et al. Development of genetic diagnostic methods for novel coronavirus 2019 (nCoV-2019) in Japan. Japanese journal of infectious diseases. 2020:JJID-2020.
  11. Ashrafi MR, Azizimalamiri R, Badv RS, Tavasoli AR, Nikkhah A, Montazerlotfelahi H, et al. Coronavirus, its neurologic manifestations, and complications. Iranian Journal of Pediatrics. 2020;30(2):1-4.
  12. Yu F, Du L, Ojcius DM, Pan C, Jiang S. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes and infection. 2020 Mar 1;22(2):74-9.
  13. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The lancet. 2020 Feb 22;395(10224):565-74.
  14. Moriguchi T, Harii N, Goto J, Harada D, Sugawara  H,   Takamino J,   et al.   A   first  case  of meningitis/encephalitis associated with SARS-Coronavirus-2. International journal of infectious diseases. 2020 May 1;94:55-8.
  15. Paniz‐Mondolfi A, Bryce C, Grimes Z, Gordon RE, Reidy J, Lednicky J, et al. Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Journal of medical virology. 2020 Jul;92(7):699-702.
  16. Zoghi A, Ramezani M, Roozbeh M, Darazam IA, Sahraian MA. A case of possible atypical demyelinating event of the central nervous system following COVID-19. Multiple sclerosis and related disorders. 2020 Sep 1;44:102324.
Journal of Cardio-Thoracic Medicine
Volume 10, Issue 4
Autumn 2022
Pages 1089-1093