Clinical Profile of Lung Cancer in Visakhapatnam, India: A Three Year Study

Document Type : Original Article

Authors

Professor , Department of Pulmonary Medicine , Andhra Medical College , Visakhapatnam , India.

Abstract

Introduction : Lung malignancy is the main and utmost type of cancer cases and mortality with raising trends in recent decades particularly in emergent countries like India. Lung malignancy can be suspected when patient presents with clinical symptoms like cough, hemoptysis or incidental abnormality on chest x-ray/ Computed Tomography or by screening with low-dose CT.
Material and Methods : A retrospective observational study done at Government hospital for chest and communicable diseases under Andhra Medical College, India from Jan 2017 to Dec 2019. Patients diagnosed with bronchogenic carcinoma either inpatient or outpatient were taken into consideration for analysis.
Results :   A total of 173 subjects were considered in study for analysis. Mean age found to be 57.67±11.36 years. 121 patients were male and 52 were female. 69.36% patients belonged to rural areas. 82.08% which accounted for 142 patients were smokers. Mean smoking index was 258±246.63. Most common presentation was cough and sob i.e., 83.24%. Most common radiological presentation was mass i.e., 54.3% (94) followed by pleural effusion in 24 cases (13.8%). Adenocarcinoma was observed in 83 patients (48%) followed by squamous cell in 61 patients (35%).
Conclusion:  Lung cancer was more common in elderly subjects  with age >50 years with  mean age of presentation in females being  lower than males. Adenocarcinoma was the predominant histological type in both males and females. Smoking still continues to be the main and important risk factor for lung cancer.

Keywords

References

  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018 Nov;68(6):394-424.
  2. Mathur P, Sathishkumar K, Chaturvedi M, Das P, Sudarshan KL, Santhappan S, et al. Cancer statistics, 2020: report from national cancer registry programme, India. JCO Global oncology. 2020 Jul;6:1063-75.
  3. Dar M, Sharma K. Burden of cancer in India: GLOBOCAN 2018 estimates incidence, mortality, prevalence and future projections of cancer in India. JETIR. 2019;6:505-14.
  4. Valaitis J, Warren S, Gamble D. Increasing incidence of adenocarcinoma of the lung. Cancer. 1981 Mar 1;47(5):1042-6.
  5. Janssen-Heijnen ML, Coebergh JW. The changing epidemiology of lung cancer in Europe. Lung cancer. 2003 Sep 1;41(3):245-58.
  6. Thun MJ, Henley SJ, Burns D, Jemal A, Shanks TG, Calle EE. Lung cancer death rates in lifelong nonsmokers. Journal of the National Cancer Institute. 2006 May 17;98(10):691-9.
  7. Wakelee HA, Chang ET, Gomez SL, Keegan TH, Feskanich D, Clarke CA, et al. Lung cancer incidence in never-smokers. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2007 Feb 2;25(5):472.
  8. Behera D, Balamugesh T. Lung cancer in India. Indian J Chest Dis Allied Science 2004; 46: 269. 2012;81.
  9. Singh N, Aggarwal AN, Gupta D, Behera D, Jindal SK. Unchanging clinico-epidemiological profile of lung cancer in north India over three decades. Cancer epidemiology. 2010 Feb 1;34(1):101-4.
  10. Noronha V, Dikshit R, Raut N, Joshi A, Pramesh CS, George K, et al. Epidemiology of lung cancer in India: Focus on the differences between non-smokers and smokers: A single-centre experience. Indian journal of cancer. 2012 Jan 1;49(1):74.
  11. Malik PS, Sharma MC, Mohanti BK, Shukla NK, Deo SV, Mohan A, et al. Clinico-pathological profile of lung cancer at AIIMS: A changing paradigm in India. Asian pacific journal of cancer prevention. 2013;14(1):489-94.
  12. Islami F, Torre LA, Jemal A. Global trends of lung cancer mortality and smoking prevalence. Translational lung cancer research. 2015 Aug;4(4):327.
  13. Parkin DM, Pisani P, Lopez AD, Masuyer E. At least one in seven cases of cancer is caused by smoking. Global estimates for 1985. International journal of cancer. 1994 Nov 15;59(4):494-504.
  14. Dubey N, Arti J, Varudkar H. A clinico-pathological profile of primary lung cancer patients presenting in a rural medical College of central India. Panacea Journal of Medical Sciences. 2016;5:124-9.
  15. Mohan A, Garg A, Gupta A, Sahu S, Choudhari C, Vashistha V, et al. Clinical profile of lung cancer in North India: A 10-year analysis of 1862 patients from a tertiary care center. Lung India: official organ of Indian Chest Society. 2020 May;37(3):190.
  16. Thakkar D, Damor P, Vithalani K. Clinicopathological profile of patients with bronchogenic carcinoma at a tertiary care center in Western India. Indian Journal of Respiratory Care. 2019 Jul 1;8(2):80.
  17. Bharate Ramesh Tukaram, D G Mhaisekar, Anil Maske. Clinical profile of lung cancer patients. MedPulse International Journal of Medicine. February 2017; 1(2): 54-58.
  18. Bhadke BB, Rathod RK, Deshmukh DG, Luniya AB, Mahajan P, Surjushe AU. Clinical profile of lung cancer in rural medical college of Maharashtra (India): a prospective study of three years. Int J Med Res Rev. 2016;4(6):1063-71.
  19. Dattatreya SP, Bansal R, Vamsy M, Vaniawala S, Nirni SS, Dayal M, Sharma R. Clinicopathological profile of lung cancer at a tertiary care center. Indian Journal of Cancer. 2018 Jul 1;55(3):273.
  20. Jindal SK, Malik SK, Dhand R, Gujral JS, Malik AK, Datta BN. Bronchogenic carcinoma in Northern India. Thorax. 1982 May 1;37(5):343-7.
  21. Dey A, Biswas D, Saha SK, Kundu S, Sengupta A. Comparison study of clinicoradiological profile of primary lung cancer cases: An Eastern India experience. Indian journal of cancer. 2012 Jan 1;49(1):89.
  22. Behera D, Balamugesh T. Lung cancer in India. Indian J Chest Dis Allied Science 2004; 46: 269. 2012;81.
  23. Chhajed PN, Athavale AU, Shah AC. Clinical and pathological profile of 73 patients with lung carcinoma: is the picture changing?. The Journal of the Association of Physicians of India. 1999 May 1;47(5):483-7.
  24. Dhandapani S, Srinivasan A, Rajagopalan R, Chellamuthu S, Rajkumar A, Palaniswamy P. Clinicopathological profile of lung cancer patients in a teaching hospital in South India. Journal of Cardio-Thoracic Medicine. 2016;4(2):440-3.
  25. Mohan A, Latifi AN, Guleria R. Increasing incidence of adenocarcinoma lung in India: Following the global trend?. Indian journal of cancer. 2016 Jan 1;53(1):92.
Journal of Cardio-Thoracic Medicine
Volume 10, Issue 4
December 2022
Pages 1065-1070

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