Association of Venous Thromboembolism and Inflammatory Bowel Disease

Document Type : Review Article

Authors

1 Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Student Research Committee, Islamic Azad University, Mashhad Branch, Mashhad, Iran.

3 Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Department of Internal Medicine, University of Toronto, Toronto, Canada.

Abstract

Introduction: Studies have shown that patients with inflammatory bowel disease (IBD) have an increased risk for venous thromboembolism (VTE). VTEs causes significant morbidity and mortality.
Methods: We carried out a comprehensive search through different online databases including PubMed, Google Scholar, Scopus, and Medline. We focused on some of patients-related factors that may affect the risk of VTE incidence among IBD patients and also reviewed current guidelines on the prophylactic regimen of the IBD patients.
Results: Based on the previous studies, the hypercoagulable nature of the disease results from a complex interaction between the systems participating in the coagulation cascade, including endothelial cells, platelets, and coagulation factors. There are a number of clinical factors that increase the probability of VTE development which include disease activity, age, pregnancy, surgery, and medical treatment.
Conclusion: Taken together, these data suggest to initiate prophylactic regimen in IBD patients and to adjust it regarding to the patient’s condition and the presence of other predisposing factors.

Keywords

References

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Journal of Cardio-Thoracic Medicine
Volume 11, Issue 2
June 2023
Pages 1167-1176

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