Tacrolimus Levels in Saliva and Serum after Heart Transplantation - Comparative Analysis Document

Document Type : Original Article


1 Department of Thoracic Surgery, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad, Iran

2 Thoracic sugeon

3 4 Clinical Pharmacy Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Assistant Prof. of Cardiology, Fellowship of Heart Failure. Preventive Cardiovascular Care Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences

5 Associated Professor, Department of cardiac surgery, Atherosclerosis Prevention Research Center, Faculity of medical science, Imam Reza Hospital, Mashhad University of Medical Sciences, Iran.

6 paracetamol; acetaminophen; cardiac surgery; pain management

7 Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

8 5th azar hospital



Introduction:Considering that the lack of correct understanding of tacrolimus serum levels leads to irreversible complications such as kidney failure, convulsions, etc. in heart transplant patients, it is very important to understand the factors affecting the metabolism and serum levels of this drug. In addition, saliva can be used as a more accessible source to measure tacrolimus levels.

Materials and Methods: In our study, 7 patients including 4 men and 3 women were included in the study, 3 patients due to DCM, 1 patient due to myocarditis, 1 patient due to ICM, 1 patient due to ARVC and 1 patient due to RHD underwent heart transplant surgery.: In this study, we aim to compare the levels of tacrolimus in the saliva and serum of patients after heart transplantation. We hypothesize that there may be a correlation between the levels of tacrolimus in saliva and serum, as both are potential sources for drug monitoring in heart transplant patients.

Results:Our study highlights the importance of accurately monitoring tacrolimus levels in heart transplant patients. While saliva-based monitoring of tacrolimus levels may be a convenient alternative to blood draw, our findings suggest that it may not provide accurate

Conclusion: These findings indicate that caution should be exercised when using salivary tacrolimus levels as a sole indicator of drug concentration and further research is necessary to better understand and interpret salivary tacrolimus levels in clinical practice and to optimize post-transplant care for heart transplant patients.