COVID-19 Severity and Prognosis Prediction: An Investigation of The Current Available Criteria

Document Type : Original Article

Authors

1 Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Department of Social Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Student Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran.

4 Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.

5 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

6 Lung Diseases Research Center, Mashhad University of Medical Science, Mashhad, Iran.

Abstract

Introduction:   Since its prevalence, Covid-19 has become one of the biggest health problems around the world, which has resulted in the loss of millions of lives. Considering preventive measures, both virulence and contagion of the disease must be  considered the first essential step in reducing the burden of the disease and its mortality; therefore, the present study is to determine the epidemiological characteristics affecting the survival rate and severity of Covid-19 in 564 patients hospitalized in Imam Reza (AS) Mashhad Hospital, in a one-year-period since 2018.
Methods: Patients admitted to the COVID-19 wards of Imam Reza (AS) Hospital in the period from March 2020 to January 2021 were included in the study and after collecting information through the designed checklist, the obtained data was entered into SPSS 26 software and analyzed statistically.
Results: Out of 564 patients with a mean (standard deviation) age of 58.8 (16.7) years, 338 (59.9%) were male. A significant relationship was observed between increasing age, male gender, underlying hypertension disease, the duration of symptoms until hospitalization, NEWS score before hospitalization and the increase in the mortality rate of patients (p<0.05). Also, the strongest relationship was observed between increasing age and mortality (P-value = 0.001 and df = 65.9, and 95%CI = 6.6-18.2).
Conclusion: As people over the age of 50 alongside patients with underlying disease are at a higher risk of getting affected, special measures and policies must be considered in this matter. Also, using the NEWS scoring system can help in predicting the prognosis of the disease.

Keywords


  1. Shaw K. The 2003 SARS outbreak and its impact on infection control practices. Public health. 2006 Jan 1;120(1):8-14.
  2.  Organization WH. SARS (Severe Acute RespiratorySyndrome). 2019.
  3. Saeedi N, Gohari NS, Ghalibaf AA, Dehghan A, Owlia MB. COVID-19 infection: a possible induction factor for development of autoimmune diseases?. Immunologic Research. 2023 Aug;71(4):547-53.
  4.  Matsuyama R, Nishiura H, Kutsuna S, Hayakawa K, Ohmagari N. Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis. BMC public health. 2016 Dec;16:1-0.
  5. Hui DS, Azhar EI, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China. International journal of infectious diseases. 2020 Feb 1;91:264-6.
  6. Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Annals of internal medicine. 2020 May 5;172(9):577-82.
  7.  da Rosa Mesquita R, Francelino Silva Junior LC, Santos Santana FM, Farias de Oliveira T, Campos Alcântara R, Monteiro Arnozo G, et al. Clinical manifestations of COVID-19 in the general population: systematic review. Wiener klinische Wochenschrift. 2021 Apr;133(7):377-82.
  8. Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Florencio LL, Cuadrado ML, Plaza-Manzano G, Navarro-Santana M. Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis. European journal of internal medicine. 2021 Oct 1;92:55-70.
  9. Oran DP, Topol EJ. Prevalence of asymptomatic SARS-CoV-2 infection: a narrative review. Annals of internal medicine. 2020 Sep 1;173(5):362-7.
  10. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. jama. 2020 Apr 7;323(13):1239-42.
  11. RECOVERY Collaborative Group. Effect of hydroxychloroquine in hospitalized patients with Covid-19. New England Journal of Medicine. 2020 Nov 19;383(21):2030-40.
  12. Pathak SK, Salunke AA, Thivari P, Pandey A, Nandy K, Ratna HV, et al. No benefit of hydroxychloroquine in COVID-19: results of systematic review and meta-analysis of randomized controlled trials”. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020 Nov 1;14(6):1673-80.
  13. Niroumand S, Mastour H, Ghalibaf AM, Shamshirian A, Moghadasin M. Medical Students' Attitude Toward E-learning During the COVID-19 Pandemic. Shiraz E-Medical Journal. 2022;23(9).
  14. Azarbakhsh H, Jokari K, Moftakhar L, Ghojogh MG, Karimyan A, Salmanzadeh S, et al. Epidemiological characteristics of patients with COVID-19 in Southwest of Iran from February 19 to June 20, 2020. Medical journal of the Islamic Republic of Iran. 2021;35:116.
  15.  Nikpouraghdam M, Farahani AJ, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, et al. Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. Journal of Clinical Virology. 2020 Jun 1;127:104378.
  16.  Wang F, Cao J, Yu Y, Ding J, Eshak ES, Liu K, et al. Epidemiological characteristics of patients with severe COVID-19 infection in Wuhan, China: evidence from a retrospective observational study. International journal of epidemiology. 2020 Dec 1;49(6):1940-50.
  17.  Marik PE, Taeb AM. SIRS, qSOFA and new sepsis definition. Journal of thoracic disease. 2017 Apr;9(4):943.
  18. Abbott TE, Vaid N, Ip D, Cron N, Wells M, Torrance HD, et al. A single-centre observational cohort study of admission National Early Warning Score (NEWS). Resuscitation. 2015 Jul 1;92:89-93.
  19.  COVID-19 Information for Older Adults | cdc. wwwcdcgov. 2021.
  20.  Bulut C, Kato Y. Epidemiology of COVID-19. Turkish journal of medical sciences. 2020;50(9):563-70.
  21.  Cunningham JW, Vaduganathan M, Claggett BL, Jering KS, Bhatt AS, Rosenthal N, et al. Clinical outcomes in young US adults hospitalized with COVID-19. JAMA internal medicine. 2021 Mar 1;181(3):379-81.
  22. Emami A, Javanmardi F, Pirbonyeh N, Akbari A. Prevalence of underlying diseases in hospitalized patients with COVID-19: a systematic review and meta-analysis. Archives of academic emergency medicine. 2020;8(1).
  23.  Yang J, Zheng YA, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. International journal of infectious diseases. 2020 May 1;94:91-5.
  24.  Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. European Respiratory Journal. 2020 May 1;55(5).
  25.  Reynolds HR, Adhikari S, Pulgarin C, Troxel AB, Iturrate E, Johnson SB, et al. Renin–angiotensin–aldosterone system inhibitors and risk of Covid-19. New England Journal of Medicine. 2020 Jun 18;382(25):2441-8.
  26.  Hippisley-Cox J, Young D, Coupland C, Channon KM, San Tan P, Harrison DA, et al. Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people. Heart. 2020 Oct 1;106(19):1503-11.
  27.  Mackey K, King VJ, Gurley S, Kiefer M, Liederbauer E, Vela K, et al. Risks and impact of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers on SARS-CoV-2 infection in adults: a living systematic review. Annals of internal medicine. 2020 Aug 4;173(3):195-203.
  28. Pranata R, Lim MA, Huang I, Raharjo SB, Lukito AA. Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: a systematic review, meta-analysis and meta-regression. Journal of the renin-angiotensin-aldosterone system: JRAAS. 2020 Apr;21(2).
  29. Ahnach M, Zbiri S, Nejjari S, Ousti F, Elkettani C. C-reactive protein as an early predictor of COVID-19 severity. Journal of medical biochemistry. 2020 Oct 10;39(4):500.
  30. Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z. Plasma CRP level is positively associated with the severity of COVID-19. Annals of clinical microbiology and antimicrobials. 2020 Dec;19:1-7.
  31. Abrishami A, Eslami V, Arab-Ahmadi M, Alahyari S, Azhideh A, Sanei-Taheri M. Prognostic value of inflammatory biomarkers for predicting the extent of lung involvement and final clinical outcome in patients with COVID-19. Journal of Research in Medical Sciences. 2021 Jan 1;26(1):115.
  32. Sahu BR, Kampa RK, Padhi A, Panda AK. C-reactive protein: a promising biomarker for poor prognosis in COVID-19 infection. Clinica chimica acta. 2020 Oct 1;509:91-4.
  33.  Francone M, Iafrate F, Masci GM, Coco S, Cilia F, Manganaro L, et al. Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. European radiology. 2020 Dec;30:6808-17.
  34. Maitra S, Som A, Bhattacharjee S. Accuracy of quick Sequential Organ Failure Assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) criteria for predicting mortality in hospitalized patients with suspected infection: a meta-analysis of observational studies. Clinical Microbiology and Infection. 2018 Nov 1;24(11):1123-9.
  35.  Liu S, Yao N, Qiu Y, He C. Predictive performance of SOFA and qSOFA for in-hospital mortality in severe novel coronavirus disease. The American Journal of Emergency Medicine. 2020 Oct 1;38(10):2074-80.
  36. Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Jama. 2016 Feb 23;315(8):775-87.
  37. Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJ, et al. Prognostic accuracy of the quick sequential organ failure assessment for mortality in patients with suspected infection: a systematic review and meta-analysis. Annals of internal medicine. 2018 Feb 20;168(4):266-75.
  38.  Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama. 2016 Feb 23;315(8):801-10.
  39. Goulden R, Hoyle MC, Monis J, Railton D, Riley V, Martin P, et al. qSOFA, SIRS and NEWS for predicting inhospital mortality and ICU admission in emergency admissions treated as sepsis. Emergency Medicine Journal. 2018 Jun 1;35(6):345-9.
  40. Baker KF, Hanrath AT, van der Loeff IS, Kay LJ, Back J, Duncan CJ. National Early Warning Score 2 (NEWS2) to identify inpatient COVID-19 deterioration: a retrospective analysis. Clinical Medicine. 2021 Mar 1;21(2):84-9.