The Potential Role of MicroRNAs in Cardiac Myxoma: A comprehensive Review on the Current Evidence

Articles in Press

Document Type : Review Article

Authors

Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

10.22038/jctm.2025.89910.1499

Abstract

Cardiac myxoma (CM) is the most common primary cardiac tumor, often benign but potentially life-threatening due to embolic events and intra-cardiac obstruction. Recent advances suggest a significant role for microRNAs (miRNAs) in CM pathogenesis, diagnosis, and treatment. This review aims to synthesize current evidence regarding the diagnostic implications of miRNAs in cardiac myxoma. Several miRNAs, including miR-217, miR-218, miR-335, miR-320a, miR-122, and miR-634, have been implicated in regulating proliferation, apoptosis, inflammation, and differentiation in CM. Notably, miR-217 and miR-218 act as tumor suppressors, while dysregulated pathways involving Myocyte Enhancer Factor 2D (MEF2D) and Interleukin-6 (IL-6) further elucidate the molecular basis of tumor progression. Circulating miRNA profiles also offer potential as non-invasive diagnostic biomarkers. miRNAs offer promising avenues for both early detection and targeted therapy in cardiac myxoma. Further research into miRNA-based diagnostics and therapeutics may enhance personalized treatment and reduce recurrence risk in affected patients.

Keywords

References

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Articles in Press, Accepted Manuscript
Available Online from 12 August 2025

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