Acute Kidney Injury after Coronary Artery Bypass Grafting in Diabetic and Non-Diabetic Patients

Document Type : Original Article

Authors

1 Department of Anesthesia and Critical Care, Faculty of Medicine, Mashhad University of medical sciences, Mashhad, Iran.

2 The clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Department of Cardiovascular Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: In recent years, there has been a lack of reliable studies comparing the incidence of acute renal failure after coronary artery bypass grafting (CABG) in patients with and without diabetes. The present study aims to compare the frequency of acute kidney injury (AKI) in diabetic patients and non-diabetics who underwent CABG.
Methods and Materials: All patients aged 40-85 years undergoing on-pump beating CABG surgery and admitted to the cardiac surgery intensive care unit (ICU) between April 2017 and April 2025 were included in the study. Patients were divided into two groups: the control group (non-diabetic patients) and the case group (diabetic patients). Information was extracted from the patients' files, and the incidence of AKI was monitored daily based on changes in creatinine and glomerular filtration rate (GFR) according to the acute kidney injury network (AKIN) criteria.
Results: A total of 214 patients were included in the study, with 104 patients (48.60%) diagnosed with diabetes. There were without no significant differences between the two groups in terms of gender (p=0.386), age (p=0.774), weight (p=0.514), body mass index (BMI) (p=0.143) and ejection fraction (EF) (p=0.055). Regarding the incidence of AKI, there was no significant difference between the two groups based on AKI on the first day after surgery (p=0.347). However, there was significant difference between the two groups based on AKI on the second day after surgery (p=0.013).
Conclusion: The results of the present study showed that the incidence and severity of AKI on the second day after surgery were lower in patients with diabetes compare to non-diabetic patients.

Keywords

References

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Journal of Cardio-Thoracic Medicine
Volume 13, Issue 3
September 2025
Pages 1578-1584

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