A Game Changer for Low and Middle Income Countries: Del Nido Cardioplegia for Adult Cardiac Surgery – A Tertiary Care Experience

Document Type : Original Article

Authors

1 Department of Cardiothoracic and Vascular Surgery, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, India.

2 Department of Anesthesia, GCS Medical College, Hospital and Research Center, Ahmedabad, Gujarat, India.

3 Department of Orthodontics and Dentofacial Orthopedics, College of Dental Sciences, Amargarh, Bhavnagar, Gujarat, India.

Abstract

Introduction: Del Nido Cardioplegia (DNC) offers prolonged myocardial protection through a single-dose approach.
Methods: This retrospective study involved 175 adult patients from five surgical groups (DVR, MIS‑MVR, MVR via sternotomy, AVR, congenital repairs). Statistical analysis was conducted using SPSS v25. Quantitative variables were assessed using t‑tests /Mann–Whitney U tests, while categorical variables were analyzed using chi‑square/Fisher’s exact tests. Significant differences (p<0.05) in ACC and CPB durations were observed across the groups.
Results: The return to spontaneous sinus rhythm ranged from 90% to 100% among the groups. Significant variations in ACC and cardiopulmonary bypass (CPB) times were noted (p<0.05). Single‑dose DNC proved to be effective in all cases.
Conclusion: DNC demonstrates safety and efficiency in low- and middle-income country (LMIC) settings.

Keywords

References

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Journal of Cardio-Thoracic Medicine
Volume 14, Issue 1
March 2026
Pages 1629-1637

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