Hematologic Abnormalities in Cyanotic Congenital Heart Disease Patients

Document Type : Original Article

Authors

1 Cardiologist, Department of Cardiology, Faculty of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2 Cardiologist,Shahid Rajaee Heart Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

3 Cardiologist ,Cardiovascular Research Center, faculty of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

4 Cardiovascular Research Center, Faculty of Medicine, Quaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction:Patients with cyanotic heart disease may have an acceptable quality of life. However, they are invariably prone to several complications. The aim of this study is search about hematologic abnormalities in cyanotic congenital heart disease patients.
Materials and Methods:  In this cross sectional study every cyanotic congenital heart disease patients who was referred to the adult congenital heart disease clinic was selected and asked of any possible hyperviscosity symptoms, gingival bleeding, Epistaxis, hemoptysis, hypermenorrhagia and gouty arthritis irrespective of their age, gender and primary diagnosis in a six-month period.
In this regard, 02 saturation was obtained via pulse oximetry, an abdominal ultrasound was done in order to discover any gallstones and lab tests including CBC, coagulation parameters (bleeding time(BT),clotting time(CT), prothrombin time(PT),international ratio( INR), Ferritin, blood urea nitrogen (BUN) and creatinine (Cr) were provided as well.
Results: A total of 69 patients were enrolled in the present study. The mean age of the patients was 22.44±5.72 with a minimum of 15 and the maximum of 46 years old. Twenty two (34.4%) of them were female and 45(65.6%) were male.
Conclusion: Our patients had less hyperuricemia, there is no correlation between hyperviscosity symptoms and haematocrit level and an inverse correlation between the Ferritin level and hyperviscosity symptoms were seen.
 

Keywords

References

1. Shelonitda S. Rose, Ashish A. Shah, Donald R. Hoover, and Parvin Saidi, Cyanotic Congenital Heart Disease (CCHD) with Symptomatic Erythrocytosis.J Gen Intern Med. 2007; 22: 1775–1777
2. Hayabuchi Y, Matsuoka S, Akita H, Kuroda Y. Hyperuricaemia in cyanotic congenital heart disease. Eur J Pediatr. 1993;152:873-6
3. Perloff JK, Marelli AJ, Miner PD. Risk of stroke in adults with cyanotic congenital heart disease. Circulation. 1993;87:1954-9.
4. Konstantinos Dimopoulos, Gerhard-Paul Diller,  Georgios Giannakoulas, et al. Anemia in Adults With Congenital Heart Disease Relates to Adverse Outcome. J Am Coll Cardiol. 2009;54:2093-2100.
5. Lill MC, Perloff JK, Child JS. Pathogenesis of thrombocytopenia in cyanotic congenital heart disease. Am J Cardiol. 2006;98:254-8.
6.Kumor-Kurek M, Siudalska H. Hematologic disorders in patients with cyanotic congenital heart disease. Pol Merkur Lekarski. 1999 :7;82-4
7.Ali Ghasemi, Mohsen Horri, Yaser Salahshour. Coagulation Abnormalities in Pediatric Patients with Congenital Heart Disease: A Literature Review. 2014: 2, 141-143.
8.Denman Hammond, . Robert Stantona, Gerald S. Gilchrist, Henry Ekert. Hemostasis in cyanotic congenital heart disease. The Journal of Pediatrics, 1970: 769; 221–230
9. A B Lewis;    M D Freed;    M A Heymann;    S L Roehl;    R C Kensey. Side effects of therapy with prostaglandin E1 in infants with critical congenital heart disease.  Circulation. 1981; 64: 893-898
10. Hitoshi Horigome, Yuji Hiramatsu, Osamu Shigeta, Toshiro Nagasawa, Akira Matsui, Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia. J Am Coll Cardiol. 2002;39:1072-1077
Journal of Cardio-Thoracic Medicine
Volume 3, Issue 1 - Serial Number 1
January 2015
Pages 270-272

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