Ghofraniha, L., Ghalenavi, E., Attaran, D., Towhidi, M., Rafatpanah, H., Khajehdaloee, M., Sarvghad Moghadam, M. (2014). A comparison of HTLV-1 Infection Frequency in Patients with or without Tuberculosis. Journal of Cardio-Thoracic Medicine, 2(2), 143-146. doi: 10.22038/jctm.2014.2608
Leila Ghofraniha; Elham Ghalenavi; Davood Attaran; Mohammad Towhidi; Hooshang Rafatpanah; Mohamad Khajehdaloee; Mohamad Reza Sarvghad Moghadam. "A comparison of HTLV-1 Infection Frequency in Patients with or without Tuberculosis". Journal of Cardio-Thoracic Medicine, 2, 2, 2014, 143-146. doi: 10.22038/jctm.2014.2608
Ghofraniha, L., Ghalenavi, E., Attaran, D., Towhidi, M., Rafatpanah, H., Khajehdaloee, M., Sarvghad Moghadam, M. (2014). 'A comparison of HTLV-1 Infection Frequency in Patients with or without Tuberculosis', Journal of Cardio-Thoracic Medicine, 2(2), pp. 143-146. doi: 10.22038/jctm.2014.2608
Ghofraniha, L., Ghalenavi, E., Attaran, D., Towhidi, M., Rafatpanah, H., Khajehdaloee, M., Sarvghad Moghadam, M. A comparison of HTLV-1 Infection Frequency in Patients with or without Tuberculosis. Journal of Cardio-Thoracic Medicine, 2014; 2(2): 143-146. doi: 10.22038/jctm.2014.2608
A comparison of HTLV-1 Infection Frequency in Patients with or without Tuberculosis
1Pulmonologist, Chronic Obstructive Pulmonary Disease Research Center, Faculty of Medicine, Mashhad University of
Medical Sciences, Mashhad, Iran
2Internist, Chronic Obstructive Pulmonary Disease Research Center, Faculty of Medicine, Mashhad University of Medical
Sciences, Mashhad, Iran
3Pulmonologist, Cardio‐Thoracic Surgery & Transplant Research Center, Emam Reza Hospital, Faculty of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran.
4Immunologist, Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,
Iran
5Community Medicine Specialist, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6Infectious Disease Department, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran
Abstract
Introduction: To recognize the predisposing factors in tuberculosis as an endemic infection in Northeast province of Iran, this study was aimed to evaluate whether HumanT-lymphocyte type 1 (HTLV-I) as an immunosuppressive factor increases the risk of tuberculosis. Materials and Methods: A Case-control study was conducted in 278 tuberculosis patients from 2007 to 2010, in Mashhad, Iran. Tuberculosis has been diagnosed by gold standard tests like sputum culture, bronchoalveolar lavage (BAL) culture or cytology. For detection of HTLV-I antibody, Enzyme Linked Immunosorbant Assay method and western Blot as the confirming test were performed. Then 276 healthy cases were matched for gender and age. Results: The mean age of tuberculosis patients was 49.67±21.36 years and for control cases was 48.36±20.74. In patients group, 114 (41.6%) were male, 160 (58.4%) were female and in controls 123 (44.6%) were male and 153 (55.4%) were female. Pulmonary tuberculosis was presented in 84.2% of the patients. The frequency of HTLV-1 was 2.9% and 3.3% in patients and controls, respectively.HTLV-I frequency was higher in male patients and it increased by age. Conclusion: Regarding to this study, HTLV-I infection is not stand-alone sufficient for increasing the risk of tuberculosis.
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