Chronic Asthma and Gastro-Esophageal Reflux Disease: The Treatment Plans

Document Type: Review Article

Authors

1 Pulmonologist, Lung diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Emam Reza Hospital, Mashhad, Iran

2 Cardio-Thoracic Surgery & Transplant Research Center, Emam Reza hospital, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Gastro-esophageal reflux disease (GERD) regularly occurs when stomach acid moves up from the stomach into the esophagus. GERD might be associated with chronic asthma symptoms such as coughing and breathlessness. According to several studies on children and adults, GERD is proven to have a close relationship with asthma.  Medication treatment via proton-pump inhibitors (PPIs), such as Omeprazole, H2 receptor blockers (Ranitidine), and other antireflux medications, is appropriate for ameliorating GERD and asthma. Moreover, surgery is another useful approach to GERD and asthma treatment. In this regard, Nissen fundoplication (laparoscopic) is a principal surgery method. Medical and surgical antireflux therapies are recognized as effective methods in the treatment of GERD-associated asthma. Our  review included studies that evaluated treatment of GERD-associated asthma. These studies accentuated the critical role of acid reflux suppression in relieving the patients suffering from a difficult to control asthma.

Keywords


  1.  Murray JF. Ch. 38 Asthma. In: Mason RJ, Murray JF, Broaddus V C, Nadel JA, Martin TR, King Jr, et al.  Murray and Nadel's textbook of respiratory medicine. 5th ed. Elsevier. ISBN 1-4160-4710-7.
  2. Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur Respir J. 2007; 29 : 179–84.
  3.  Kelly FJ, Fussell JC. Air pollution and airway disease. Clinical and experimental allergy : Clin Exp Allergy. 2011; 41: 1059–71
  4.  Boulet LP. Influence of comorbid conditions on asthma. Eur Respir J. 2009; 33 : 897–906.
  5. DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. The Practice Parameters Committee of the American College of Gastroenterology. Am J Gastroenterol. 1999; 94 : 1434–42.
  6.  Hershcovici T, Fass R. Pharmacological management of GERD: where does it stand now? Trends Pharmacol Sci. 2011; 32 : 258–64.
  7.  Zajac P, Holbrook A, Super ME, Vogt M. An overview: Current clinical guidelines for the evaluation, diagnosis, treatment, and management of dyspepsia. Osteopathic Family Physician. 2013; 5 : 79–85. 
  8.  Kahrilas PJ, Shaheen NJ, Vaezi MF, Hiltz SW, Black E, Modlin IM, et al. American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease. Gastroenterology. 2008; 135 : 1391.e1–5.
  9. Abbas AE, Deschamps C, Cassivi SD, Allen MS, Nichols FC, Miller DL, et al. The role of laparoscopic fundoplication in Barrett's esophagus. Ann Thorac Surg. 2004; 77 : 393–6.
  10. Wileman SM, McCann S, Grant AM, Krukowski ZH, Bruce J. Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults. Available from: Cochrane database of systematic reviews. 2010; 3 : CD003243.
  11. Harding SM. Recent clinical investigations examining the association of asthma and stroesophageal reflux. Am J Med. 2003;115:39S–44S.
  12. Pratter MR, Bartter T, Akers S, DuBois J. An algorithmic approach to chronic cough. Ann Intern Med. 1993;119:977–83.
  13. Harding SM. Gastroesophageal reflux, asthma, and mechanisms of interaction. Am J Med. 2001; 111 Suppl 8A:8S-12S.
  14. Moote DW, Lloyd DA, McCourtie DR, Wells GA. Increase in gastroesophageal reflux during ethacholine-induced bronchospasm. J Allergy Clin Immunol. 1986; 78 :619-623.
  15. Canning BJ, Mazzone SB. Reflex mechanisms in gastroesophageal reflux disease and asthma. Am J Med. 2003;115:45S–8S
  16. Wong CH, ChuaCJ, Liam CK,GohK L. Gastro-oesophageal reflux disease in ‘difficult-to-control’asthma: prevalence and response to treatment with acid suppressive therapy. Aliment Pharmacol Ther. 2003; 23, 1321–27.
  17. Sato A, Tanifuji Y, Kobayashi H, Inoue H. Effects of proton pump inhibitor on airway hyperresponsiveness in asthmatics with gastroesophageal reflux. b. Arerugi. 2006 ;55:641-6.
  18. Kiljander TO, Salomaa ER, Hietanen EK, Terho EO. Gastroesophageal reflux in asthmatics: A double-blind, placebo-controlled crossover study with Omeprazole. Chest. 2001; 120:691.
  19. Harding SM, Richter JE, Guzzo MR, Schan CA, Alexander RW, Bradley LA. Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome. Am J Med. 1996; 100:395-405.
  20. Meier JH, McNally PR, Punja M, Freeman SR, Sudduth RH, Stocker N, et al. improve respiratory function in asthmatics with gastroesophageal reflux? A double-blind, placebo-controlled crossover study. Am J Med. 1996;100:3
  21. Depla AC1, Bartelsman JF, Roos CM, Tytgat GN, Jansen HM. Beneficial effect of Omeprazole in a patient with severe bronchial asthma and gastro-oesophageal reflux. Eur Respir J. 1988; 1:966-8.
  22. Sharma B, Sharma M, Daga MK, Sachdev GK, Bondi E. Effect of Omeprazole and domperidone on adult asthmatics with gastroesophageal reflux. World J Gastroenterol. 2007; 21; 13: 1706–1710.
  23. Alexander JA, Hunt LW, Patel AM. Prevalence, pathophysiology, and treatment of patients with asthma and gastroesophageal reflux disease. Mayo Clin Proc. 2000; 75:1055-63.
  24. Ekström T, Lindgren BR, Tibbling L. Effects of Ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blind crossover study. Thorax. 1989; 44:19-23.
  25. Gustafsson PM, Kjellman NI, Tibbling L. A. Trial of Ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux. Eur Respir J. 1992;5:201-6.
  26. Farcău D, Dreghiciu D, Cherecheş-Panţa P, Popa M, Farcău M, Nanulescu M. Effectiveness of antireflux therapy in asthmatic children with gastroesophageal reflux disease. Pneumologia. 2004; 53:207-11.
  27. Harper PC, Bergner A, Kaye MD. Antireflux treatment for asthma. Improvement in patients with associated gastroesophageal reflux. Arch Intern Med. 1987; 147:56-60
  28. dos Santos LH, Ribeiro IO, Sánchez PG, Hetzel JL, Felicetti JC, Cardoso PF. Evaluation of pantoprazol treatment response of patients with asthma and gastroesophageal reflux: a randomized prospective double-blind placebo-controlled study. J Bras Pneumol. 2007; 33:119-27.
  29. Tsugeno H1, Mizuno M, Fujiki S, Okada H, Okamoto M, Hosaki Y, et al. A proton-pump inhibitor, Rabeprazole, improves ventilatory function in patients with asthma associated with gastroesophageal reflux. Scand J Gastroenterol. 2003; 38:456-61.
  30. Sontag S. J., O’Connell S., Khandelwal S., Greenlee H., Schnell T., Nemchausky B. et al. Asthmatics With Gastroesophageal Reflux: Long Term Results of a Randomized Trial of Medical and Surgical Antireflux Therapies. Am J Gastroenterol. 2003; 98:987-99.
  31. Augusto Larrain, Edgardo Carrasco, Fabian Galleguillos, Ricardo Sepulveda, Charles E. Pope ii. Medical and Surgical Treatment of Nonallergic Asthma Associated with Gastroesophageal Reflux. Chest . 1991; 99-6.
  32. Silva AP, Tercioti-Junior V, Lopes LR, Coelho-NetoJde S, Bertanha L, Rodrigues PR1, et al. Laparoscopic antireflux surgery in patients with extra esophageal symptoms related to asthma. Arq Bras Cir Dig. 2014; 27:92-5.
  33. Kaufman JA1, Houghland JE, Quiroga E, Cahill M, Pellegrini CA, Oelschlager BK. Long-term outcomes of laparoscopic antireflux surgery for gastroesophageal reflux disease (GERD)-related airway disorder. Surg Endosc. 2006; 20:1824-30.
  34. Chen D, Barber C, McLoughlin P, Thavaneswaran P, Jamieson GG, Maddern GJ. Systematic review of endoscopic treatments for gastro-oesophageal reflux disease. Br J Surg. 2009 ;96:128–136. 
  35. Spicák J. Treatment of gastroesophageal reflux disease: endoscopic aspects. Dig Dis. 2007 ;25:183–187.
  36. Jafri SM, Arora G, Triadafilopoulos G. What is left of the endoscopic antireflux devices?. Curr Opin Gastroenterol. 2009 ;25:352–357
  37. White B, Jeansonne LO, Cook M, Chavarriaga LF, Goldenberg EA, Davis SS, et al. Use of endoluminalantireflux therapies for obese patients with GERD. Obes Surg. 2009; 19:783–787.
  38. Comay D, Adam V, da Silveira EB, Kennedy W, Mayrand S, Barkun AN. The Stretta procedure versus proton pump inhibitors and laparoscopic Nissen fundoplication in the management of gastroesophageal reflux disease: a cost-effectiveness analysis. Can J Gastroenterol. 2008; 22:552–558. 
  39.   Higuchi K, Fujiwara Y, Okazaki H, Tabuchi M, Kameda N, Kadouchi K, et al. Feasibility, safety, and efficacy of the Stretta procedure in Japanese patients with gastroesophageal reflux disease: first report from Asia. J Gastroenterol. 2007; 42:205–210. 
  40. Aziz AM, El-Khayat HR, Sadek A, Mattar SG, McNulty G, Kongkam P, et al. A prospective randomized trial of sham, single-dose Stretta, and double-dose Stretta for the treatment of gastroesophageal reflux disease. Surg Endosc. 2010; 24:818–825. 
  41.   Liang WT, Wu JM, Wang F, Hu ZW, Wang ZG. Stretta radiofrequency for gastroesophageal reflux disease-related respiratory symptoms: a prospective 5-year study. Minerva Chir. 2014 ;69:293-9.