An Unusual Presentation of Granulomatosis with Polyangiitis

Document Type: Case Report

Authors

1 Internal Medicine, Pulmonologist, Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Dehradun,Indian

2 Critical Care Medicine, Department of Critical Care Medicine, Himalayan Insitute of Medical Sciences, Dehradu, Indian

3 Senior Resident, Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Dehradun, Indian

4 Pathologist, Department of Pathology, Himalayan Institute of Medical Sciences, Dehradun, Indian

5 Resident, Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Dehradun, Indian

Abstract

The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN).
The antinuclear (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) are considered as relatively specific markers of the disease. Herein, we presented the case of a patient who initially presented with sepsis but did not respond to the conventional antibiotics and later diagnosed with GPA.The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN).
The antinuclear (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) are considered as relatively specific markers of the disease. Herein, we presented the case of a patient who initially presented with sepsis but did not respond to the conventional antibiotics and later diagnosed with GPA.

Keywords


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