Clinical and Para-Clinical Presentations of Endobronchial Tuberculosis

Document Type : Original Article

Authors

1 Pulmonologist , Lung Disease Research Center, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

2 Internist, Department of Internal Medicine, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

3 Pulmonologist, Lung Disease Research Center, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introdution: Tuberculosis (TB), with different types of respiratory tract involvements, has a high rate of mortality all around the world. Endobronchial involvement, which is a slightly common tuberculous infection, requires special attention due to its severe complications such as bronchostenosis.
Aim of study of this study was describes, one type of pulmonary tuberculosis with less diagnosed and delayed treatment. High suspicious needs to diagnose and may be need bronchoscopy for confirmed the diagnosis. It can be associated with sever complication and early diagnosis and treatment are necessary for prevention of adverse effect. 
 
Materials and Methods: This retrospective study was conducted in a teaching hospital during 2005-2010. Patients diagnosed with endobronchial tuberculosis through bronchoscopic biopsy were included in the study. Diagnosis was confirmed by observation of caseous necrosis, bronchial lavage fluid or positive acid-fast staining in tissue samples obtained through bronchial biopsy. Moreover, demographic information, endobronchial view, lab tests, as well as clinical and radiographic findings were reviewed and evaluated retrospectively.
Results: A total of 20 cases were confirmed with endobronchial tuberculosis, 75% of whom were female with the mean age of 60 years. The results showed that the most common clinical symptom was cough (80%), the most common finding in the chest X-ray was consolidation (75%), and the most common bronchoscopic feature was anthracosis (55%).
Conclusion: TB is still a major concern, particularly in the developing countries. Thus, in order for early diagnosis and prevention of this disease, we need to pay meticulous attention to its clinical manifestations and bronchoscopic features.

Keywords


  1. Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med. 2003; 163:1009-21.
  2. World Health Organization. Estimates of TB and MDR-TB burden are produced by WHO in consultation with countries; 2015.
  3. Tamura A, Hebisawa A, Masuda K, Shimada M, Kunogi M, Kaneko Y, et al. Features of bronchial tuberculosis-an--analysis of 103 cases. Kekkaku. 2007; 82:647-54.
  4. Golshan M. Tuberculosis bronchitis with normal chest x-ray among a large bronchoscopic population. Ann Saudi Med. 2002; 22:98-101.
  5. Miguel Campos E, Puzo Ardanuy C, Burgués Mauri C, Castella Riera J. A study of 73 cases of bronchial tuberculosis. Arch Bronconeumol. 2008; 44:282-4.
  6. Samardzić N, Jovanović D, Marković-Denić L, Roksandić-Milenković M, Popević S, Skodrić-Trifunović V. Clinical features of endobronchial tuberculosis. Vojnosanit Pregl. 2014; 71:156-60.
  7. Bekci TT, Maden E, Emre L. Bronchial anthracofibrosis case with endobronchial tuberculosis. Int J Med Sci. 2011; 8:84-7.
  8. Ozkaya S, Bilgin S, Findik S, Kök HC, Yuksel C, Atıcı AG. Endobronchial tuberculosis: histopathological subsets and microbiological results. Multidiscip Respir Med. 2012; 7:34.
  9. Chung HS, Lee JH. Bronchoscopic assessment of the evolution of endobronchial tuberculosis. Chest. 2000; 117:385-92.
  10. Kim HJ, Kim SD, Shin DW, Bae SH, Kim AL, Kim JN, et al. Relationship between bronchial anthracofibrosis and endobronchial tuberculosis. Korean J Intern Med. 2013; 28:330-8.
  11. Xue Q, Wang N, Xue X, Wang J. Endobronchial tuberculosis: an overview. Eur J Clin Microbiol Infect Dis. 2011; 30:1039-44.
  12. Ghanei M, Aslani J, Peyman M, Ahmadzad Asl M, Pirnazar O. Bronchial anthracosis: a potent clue for diagnosis of pulmonary tuberculosis. Oman Med J. 2011; 26:19-22.